Ciprofloxacin Polymers Derived from Diallyltin and Divinyltin Dihalides

Michelangelo Scopelliti, Tiziana Fiore, Claudia Pellerito, Lorenzo Pellerito, Girish Barot, Kimberly R. Shahi, Anna Zhao, Michael R. Roner, Charles E. Carraher Jr.

Research output: Contribution to journalArticlepeer-review

8 Citations (Scopus)

Abstract

The initial synthesis of condensation polymers from newly available divinyltin dichloride and diallyltin dichloride and ciprofloxacin is accomplished employing a modified interfacial polycondensation process. The polymeric (DP are about 2,000) products are rapidly (less than 15 seconds) formed in good yield. Infrared spectroscopy shows the formation of Sn-O and Sn-N bonds as predicted from the proposed structure. F-MALDI MS also shows ion fragments containing organotin in the predicted isotopic abundances as well as ion fragments containing both organotin and ciprofloxacin. The polymers exhibit low toxicity towards healthy WI-38 cells with variable toxicities towards a variety of cancer cell lines.
Original languageEnglish
Pages (from-to)87-109
Number of pages24
JournalJournal of Polymer Materials
Volume25
Publication statusPublished - 2008

All Science Journal Classification (ASJC) codes

  • Polymers and Plastics
  • Materials Chemistry

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