Characterization of the apical membrane antigen-1 in Italian strains of Babesia bigemina

Guido Sireci; Annalisa Agnone; Mario La Farina; Ida Albanese; null Agnone; Valeria Blanda; null Cerrone; null Cusumano; null Mosqueda; Santo Caracappa; Alessandra Torina; Valeria Blanda

Characterization of the apical membrane antigen-1 in Italian strains of Babesia bigemina

Guido Sireci, Annalisa Agnone, Mario La Farina, Ida Albanese, Agnone, Valeria Blanda, Cerrone, Cusumano, Mosqueda, Santo Caracappa, Alessandra Torina, Valeria Blanda

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20 Citations (Scopus)

Abstract

Babesia bigemina is a parasite endemic in different parts of the world, including Europe and the Americas. One of the few genes characterized in this species codifies for the Apical Membrane Antigen 1 (AMA-1), a trans-membrane antigen recently identified. In this research, we characterized the ama-1 gene from three Italian B. bigemina strains, two B. bigemina strains obtained from Ragusa, Sicily (ITA1 and ITA3) and a third one obtained from Benevento, Campania (ITA2). Italian sequences were compared with those of the Australian strain obtained from the Sanger Institute web site and to strains from different parts of the world. The results obtained confirmed that this newly described ama-1 gene is highly conserved among Italian and foreign strains which has implications for vaccine development.

Original language	English
Pages (from-to)	52-56
Number of pages	5
Journal	Transboundary and Emerging Diseases
Volume	57
Publication status	Published - 2010

All Science Journal Classification (ASJC) codes

General Immunology and Microbiology
General Veterinary

Cite this

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title = "Characterization of the apical membrane antigen-1 in Italian strains of Babesia bigemina",

abstract = "Babesia bigemina is a parasite endemic in different parts of the world, including Europe and the Americas. One of the few genes characterized in this species codifies for the Apical Membrane Antigen 1 (AMA-1), a trans-membrane antigen recently identified. In this research, we characterized the ama-1 gene from three Italian B. bigemina strains, two B. bigemina strains obtained from Ragusa, Sicily (ITA1 and ITA3) and a third one obtained from Benevento, Campania (ITA2). Italian sequences were compared with those of the Australian strain obtained from the Sanger Institute web site and to strains from different parts of the world. The results obtained confirmed that this newly described ama-1 gene is highly conserved among Italian and foreign strains which has implications for vaccine development.",

keywords = "Babesia bigemina, apical membrane antigen-1, vaccine candidates, Babesia bigemina, apical membrane antigen-1, vaccine candidates",

author = "Guido Sireci and Annalisa Agnone and {La Farina}, Mario and Ida Albanese and Agnone and Valeria Blanda and Cerrone and Cusumano and Mosqueda and Santo Caracappa and Alessandra Torina and Valeria Blanda",

year = "2010",

language = "English",

volume = "57",

pages = "52--56",

journal = "Journal of Veterinary Medicine Series A: Physiology Pathology Clinical Medicine",

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publisher = "Wiley-Blackwell",

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TY - JOUR

T1 - Characterization of the apical membrane antigen-1 in Italian strains of Babesia bigemina

AU - Sireci, Guido

AU - Agnone, Annalisa

AU - La Farina, Mario

AU - Albanese, Ida

AU - Agnone, null

AU - Blanda, Valeria

AU - Cerrone, null

AU - Cusumano, null

AU - Mosqueda, null

AU - Caracappa, Santo

AU - Torina, Alessandra

AU - Blanda, Valeria

PY - 2010

Y1 - 2010

N2 - Babesia bigemina is a parasite endemic in different parts of the world, including Europe and the Americas. One of the few genes characterized in this species codifies for the Apical Membrane Antigen 1 (AMA-1), a trans-membrane antigen recently identified. In this research, we characterized the ama-1 gene from three Italian B. bigemina strains, two B. bigemina strains obtained from Ragusa, Sicily (ITA1 and ITA3) and a third one obtained from Benevento, Campania (ITA2). Italian sequences were compared with those of the Australian strain obtained from the Sanger Institute web site and to strains from different parts of the world. The results obtained confirmed that this newly described ama-1 gene is highly conserved among Italian and foreign strains which has implications for vaccine development.

AB - Babesia bigemina is a parasite endemic in different parts of the world, including Europe and the Americas. One of the few genes characterized in this species codifies for the Apical Membrane Antigen 1 (AMA-1), a trans-membrane antigen recently identified. In this research, we characterized the ama-1 gene from three Italian B. bigemina strains, two B. bigemina strains obtained from Ragusa, Sicily (ITA1 and ITA3) and a third one obtained from Benevento, Campania (ITA2). Italian sequences were compared with those of the Australian strain obtained from the Sanger Institute web site and to strains from different parts of the world. The results obtained confirmed that this newly described ama-1 gene is highly conserved among Italian and foreign strains which has implications for vaccine development.

KW - Babesia bigemina

KW - apical membrane antigen-1

KW - vaccine candidates

KW - Babesia bigemina

KW - apical membrane antigen-1

KW - vaccine candidates

UR - http://hdl.handle.net/10447/53358

M3 - Article

SN - 1865-1674

VL - 57

SP - 52

EP - 56

JO - Journal of Veterinary Medicine Series A: Physiology Pathology Clinical Medicine

JF - Journal of Veterinary Medicine Series A: Physiology Pathology Clinical Medicine

ER -

Characterization of the apical membrane antigen-1 in Italian strains of Babesia bigemina

Abstract

All Science Journal Classification (ASJC) codes

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