Characteristics of coronary microcirculatory function in patientswith Takotsubo syndrome

Salvatore Novo, Francesco Giambanco, Giuseppina Novo, Angelo Quagliana, Giovanna Geraci, Salvatore Giambanco, Dario Buccheri, Francesco Giambanco, Dario Buccheri, Salvatore Evola

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Abstract

Background: Takotsubo syndrome (TS) is a recently described cardiac syndrome whose pathogenesis isstill unclear. We investigated the characteristics of coronary microcirculatory function in patients with TSthrough the analysis of the TIMI frame count (TFC) compared to normal subjects and with to subjects withmicrovascular angina (MA).Methods: We enrolled 71 TS patients (F:M =69:2, mean age of 65.27±9.53 years), 70 controls (F:M =34:36,mean age of 56.63±13.5 years) and 71 patients with MA, (F:M =69:2, mean age of 65.9±9.2 years). Theassessment of the microcirculation was carried out through the TFC.Results: microcirculation was significantly altered in patients with TS compared with healthy controls[left anterior descending coronary artery (LAD) 25.16±6.91 vs. 17.30±3.76, P<0.001; circumflex artery (CX)25.48±6.10 vs. 17.05±4.60, P<0.001; right coronary artery (RCA) 26.43±8.95 vs. 15.74±4.27, P<0.001, averageTFC in TS 25.70±5.34 vs. 16,70±3.26, P<0.001). A TFC >20 frames was able to discriminate TS patientsfrom controls with a specificity of 88.57% and sensitivity of 85.92% (AUC 0.927, P<0.0001). Microvasculardysfunction was diffuse in TS as well as in MA and slightly more severe in this last (mean TFC in MA28.25±9.3 vs. 25.7±5.34 in TS, P<0.046).Conclusions: Coronary microcirculation in TS patients is diffuse and milder compared to MA patients.Cut-off values >20 frames discriminate between patients with normal microcirculation and patients with TS.
Original languageEnglish
Pages (from-to)4531-4537
Number of pages7
JournalJournal of Thoracic Disease
Volume9
Publication statusPublished - 2017

All Science Journal Classification (ASJC) codes

  • Pulmonary and Respiratory Medicine

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    Novo, S., Giambanco, F., Novo, G., Quagliana, A., Geraci, G., Giambanco, S., Buccheri, D., Giambanco, F., Buccheri, D., & Evola, S. (2017). Characteristics of coronary microcirculatory function in patientswith Takotsubo syndrome. Journal of Thoracic Disease, 9, 4531-4537.