Chaperonology: The third eye on brain gliomas

Francesca Graziano, Claudia Campanella, Celeste Caruso Bavisotto, Francesca Rappa, Francesco Cappello, Domenico Iacopino, Antonella Marino Gammazza, Claudia Campanella, A. Marino Gammazza, Francesca Rappa, C. Caruso Bavisotto, Everly Conway De Macario, Francesco Cappello, Everly Conway De Macario, Albert J. L. Macario

Research output: Contribution to journalArticlepeer-review

10 Citations (Scopus)


The European Organization for Research and Treatment of Cancer/National Cancer Institute of Canada Phase III trial has validated as a current regimen for high-grade gliomas (HGG) a maximal safe surgical resection followed by radiotherapy with concurrent temozolamide. However, it is essential to balance maximal tumor resection with preservation of the patient’s neurological functions. Important developments in the fields of pre-operative and intra-operative neuro-imaging and neuro-monitoring have ameliorated the survival rate and the quality of life for patients affected by HGG. Moreover, even though the natural history remains extremely poor, advancement in the molecular and genetic fields have opened up new potential frontiers in the management of this devastating brain disease. In this review, we aim to present a comprehensive account of the main current pre-operative, intra-operative and molecular approaches to HGG with particular attention to specific chaperones, also called heat shock proteins (Hsps), which represent potential novel biomarkers to detect and follow up HGG, and could also be therapeutic agents.
Original languageEnglish
Pages (from-to)110-
Number of pages13
JournalBrain Sciences
Publication statusPublished - 2018

All Science Journal Classification (ASJC) codes

  • General Neuroscience


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