Cerebral microbleeds and vascular cognitive impairment

Lisa Cipolotti, Simone M. Gregoire, David J. Werring, Lisa Cipolotti

Research output: Contribution to journalArticlepeer-review

110 Citations (Scopus)


Vascular cognitive impairment (VCI) is a key healthcare challengefacing all aging Western societies, second only to Alzheimer's Disease(AD) as a cause of dementia [1]. Initial concepts of VCI invoked corticalor subcortical infarction – leading to the terms “multi-infarctdementia” and “post-stroke dementia”. However subcortical smallvessel disease (often not causing acute or overt clinical symptoms)also plays a critical role in VCI [2–4]. MRI is the most important tool fordetecting and quantifying small vessel diseases, and forms part ofcurrent diagnostic criteria for vascular dementia [1]. MRI manifestationsof small vessel diseases including white matter hyperintensities(WMH: bright signal areas on T2-weighted or FLAIR images includingleukoaraiosis) and lacunes have been recognized for many years.Cerebral microbleeds (CMBs) – small, perviascular haemorrhagesseen as well-demarcated, rounded lesions on MRI sequences sensitiveto magnetic susceptibility – are also now recognized as a manifestationof small vessel pathology [5] (Fig. 1), but their clinical impact oncognition remains uncertain [6]. This review will consider how CMBsmay be relevant in the study of VCI.
Original languageEnglish
Pages (from-to)131-135
Number of pages5
JournalJournal of the Neurological Sciences
Publication statusPublished - 2010

All Science Journal Classification (ASJC) codes

  • Neurology
  • Clinical Neurology


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