Abstract

Abstract: A main objective of current medical research is to improve the life quality of elderly people as priority of thecontinuous increase of ageing population. This phenomenon implies several medical, economic and social problems becauseof dramatic increase in number of non autonomous individuals affected by various pathologies. Accordingly, the researchinterest is focused on understanding the biological mechanisms involved in determining the positive ageing phenotype,i.e. the centenarian phenotype. In achieving this goal the choice of an appropriate study models is fundamental. Centenarianshave been used as an optimal model for successful ageing. However, this model shows several limitations, i.e.the selection of appropriate controls and the use itself of the centenarians as a suitable model for healthy ageing. Thus, theinterest has been centered on centenarian offspring, healthy elderly people. They may represent a model for understandingexceptional longevity for the following reasons: they exhibit a protective genetic background, cardiovascular and immunologicalprofile, as well as a reduced rate of cognitive decline than age-matched people without centenarian relatives.Several of these aspects are summarized in this review based on the literature and the results of our studies.
Original languageEnglish
Pages (from-to)718-725
Number of pages8
JournalCurrent Vascular Pharmacology
Volume12
Publication statusPublished - 2014

All Science Journal Classification (ASJC) codes

  • Pharmacology
  • Cardiology and Cardiovascular Medicine

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