Cellular and molecular basis of the imbalance between vasculardamage and repair in ageing and age-related diseases: As biomarkersand targets for new treatments

    Research output: Contribution to journalArticle

    Abstract

    Preclinical and clinical studies suggest that specific subsets of cells isolated from the peripheral blood,play an essential role in the imbalance of damage and repair during age-associated diseases, such asmetabolic syndrome, diabetes, atherosclerosis, neurodegenerative diseases, osteoporosis and cancer.Endogenous regeneration of the vessel wall involves cells of the vascular wall, inflammatory cells, cir-culating precursors, and mature endothelial cells, which are capable to restore the endothelium in aconcerted interaction. Early detection of such imbalances with specific biomarkers may reduce age-associated diseases and subsequent cardiovascular events. Likewise, new strategies have the potentialityof acting selectively on these cell populations and co-temporally mediate the stimulation of the func-tion and number of those cell populations with regenerative action on the vessel, and inhibit those ableto evocate vascular damage. These strategies may be an alternative innovative way with superior andmore efficacy biological effects than conventional attempts used for treating actually vascular diseases,characterizing those co-morbidities related to ageing.
    Original languageEnglish
    Pages (from-to)1-9
    Number of pages9
    JournalMECHANISMS OF AGEING AND DEVELOPMENT
    Publication statusPublished - 2016

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