Ionizing radiations (IRs) generated by intraoperative radiotherapy (IORT) treatment activatesboth pro- and antiproliferative signal pathways producing an imbalance in cell fate decision regulated byseveral genes and factors involved in cell cycle progression, survival and/or cell death, DNA repair andinflammation. This paper describes the latest advances on cellular and molecular response to IR, highlightingthe most relevant research data from cell biology, gene expression profiling and epigenetic studies ondifferent tumor cell types. Understanding the cell molecular strategies to choose between death and survival,after an irradiation-induced damage, opens new avenues for the selection of a proper therapy schedule, tocounteract cancer growth and preserve healthy surrounding tissue by radiation effects.
|Number of pages||15|
|Journal||Translational Cancer Research|
|Publication status||Published - 2014|