Caveolin-1, breast cancer and ionizing radiation

Giusi Irma Forte, Valentina Bravata', Marzia Pucci, Luigi Minafra, Maria Carla Gilardi, Valentina Bravatà, Francesco Paolo Cammarata, Marzia Pucci, Giusi Irma Forte, Cristina Messa, Luigi Minafra

Research output: Contribution to journalArticlepeer-review

23 Citations (Scopus)

Abstract

Breast cancer (BC) recovery has increased in recent years thanks to efforts of Omics-based research in this field. However, despite the important results obtained, BC remains a complex multifactorial pathology that is difficult to treat appropriately. Caveolin-1 (CAV1), the basic constituent protein of specialized plasma membrane invaginations called caveolae, is emerging as a potential therapeutic biomarker in BC. This factor may modulate BC response to chemotherapy and radiation therapy. In addition, recent reports describe the key role of CAV1 during cell response to oxidative stress. The aim of the present review was to describe the biological roles of CAV1 in BC considering its contrasting dual functions as an oncogene and as a tumor suppressor. In addition, we report on how CAV1 may contribute to tumor cell response to ionizing radiation treatment. Finally, new roles of CAV1 in BC both on epithelium and stroma may be useful as prognostic indicators for patient treatment and help clinicians in the selection of the best personalized therapy.
Original languageEnglish
Pages (from-to)143-152
Number of pages10
JournalCANCER GENOMICS & PROTEOMICS
Volume12
Publication statusPublished - 2015

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Molecular Biology
  • Genetics
  • Cancer Research

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