Cathepsin L in metastatic bone disease: therapeutic implications

Marilena Crescimanno, Gaetano Leto, Francesca Maria Tumminello, Carla Flandina, Maria Vittoria Sepporta, Carla Flandina, Francesca Maria Tumminello, Marilena Crescimanno, Gaetano Leto

Research output: Contribution to journalArticlepeer-review

27 Citations (Scopus)


Cathepsin L is a lysosomal cysteine proteinase primarily devoted to the metabolic turnover of intracellular proteins. However, accumulating evidence suggests this endopeptidase may be also implicated in the regulation of other important biological functions including bone resorption in normal and pathological conditions. These findings support the concept that cathepsin L, in concert with other proteolytic enzymes involved in bone remodelling processes, may contribute to facilitate bone metastasis formation. In support of this hypothesis, recent studies indicate that cathepsin L may foster this process by triggering multiple mechanisms which, in part, differ from those of the major cysteine proteinase of osteoclast, namely cathepsin K. Therefore, cathepsin L may be regarded as an additional target in the treatment of patients with metastatic bone disease. This review discusses the clinical and therapeutic implications related to these findings.
Original languageEnglish
Pages (from-to)655-664
Number of pages10
JournalBiological Chemistry
Publication statusPublished - 2010

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Molecular Biology
  • Clinical Biochemistry


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