Carotid and peripheral atherosclerosis in patients who underwent primary percutaneous coronary intervention and outcome associated with multifocal atherosclerosis

Pasquale Assennato, Egle Corrado, Enrico Hoffmann, Giuseppina Novo, Salvatore Novo, Romano, Novo, Di Vincenzo, Giuseppina Novo, Ciaramitaro, Salvatore Evola, Valentina Cospite, Farinella, Antonino Rotolo, Pasquale Assennato, Enrico Hoffmann, Giuseppe Andolina, Egle Corrado, Muratori, Ida Maria MuratoriSalvatore Evola, Valentina Cospite

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

AIM: The aim of our study was to determine if patients with multifocal atherosclerosis have a worse prognosis than patients with atherosclerosis only in the coronary bed.METHODS: We studied 45 subjects admitted to intensive coronary care unit of the Division of Cardiology with the diagnosis of acute myocardial infarction (AMI). Traditional cardiovascular risk factors were investigated and laboratory analysis included measurement of plasma lipids, glycemia, fibrinogen and high-sensitivity-C-reactive protein (hs-CRP). Each patient underwent coronary-angiography as well as carotid and peripheral arterial ultrasound examination. A follow-up of 13+/-2 months was performed.RESULTS: We found that the severity of coronary atherosclerosis is significantly associated with the presence of carotid (P<0.05) and peripheral atherosclerosis (P<0.005). Markers of inflammation, hs-CRP (P<0.005) and fibrinogen (P<0.05), were significantly associated with multifocal atherosclerosis. We have shown that an increased number of coronary vessels with atherosclerotic stenosis is associated with a higher value of carotid (P<0.0001) and peripheral intima media thickness (P<0.0001). During 13 months of follow-up the incidence of fatal or non fatal events was 18%. The multivariate analysis showed that the variables independently associated with fatal and non fatal events were: male sex (P<0.001), family history of cardiovascular disease (P<0.005), hypertension (P<0.01), diabetes mellitus (P<0.05), higher levels of total cholesterol (P<0.05), smoking habit (P<0.05), and multifocal atherosclerosis (P<0.05).CONCLUSIONS: The ultrasound examination of carotid and peripheral atherosclerotic lesions may be useful in placing patients with AMI in a category of higher risk of cerebrovascular and cardiovascular events. Moreover, the precocious identification of patients at risk can suggest a more aggressive pharmacological treatment and a more accurate follow-up in order to avoid future events
Original languageEnglish
Pages (from-to)389-394
Number of pages6
JournalINTERNATIONAL ANGIOLOGY
Volume25
Publication statusPublished - 2006

All Science Journal Classification (ASJC) codes

  • Cardiology and Cardiovascular Medicine

Fingerprint Dive into the research topics of 'Carotid and peripheral atherosclerosis in patients who underwent primary percutaneous coronary intervention and outcome associated with multifocal atherosclerosis'. Together they form a unique fingerprint.

  • Cite this

    Assennato, P., Corrado, E., Hoffmann, E., Novo, G., Novo, S., Romano, Novo, Di Vincenzo, Novo, G., Ciaramitaro, Evola, S., Cospite, V., Farinella, Rotolo, A., Assennato, P., Hoffmann, E., Andolina, G., Corrado, E., Muratori, ... Cospite, V. (2006). Carotid and peripheral atherosclerosis in patients who underwent primary percutaneous coronary intervention and outcome associated with multifocal atherosclerosis. INTERNATIONAL ANGIOLOGY, 25, 389-394.