Carbonic anhydrase inhibitor with topical NSAID therapy to manage cystoid macular edema in a case of gyrate atrophy

Giovanni Cillino, Salvatore Cillino, Marco Mazza, Silvia Santambrogio, Elena Piozzi, Aissa Iggui, Marta Mazza

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Purpose: Gyrate atrophy of the choroid and retina (GACR) is a rare chorioretinal dystrophy characterized by a deficiency of the enzyme ornithine aminotransferase, inherited in an autosomal recessive pattern.Case report: We report a case of a 17-year-old girl with GACR, for whom the level of serum ornithine had been reduced by an arginine-restricted diet. The patient was responsive to an association of topical nonsteroidal anti-inflammatory drugs (NSAIDs) and a carbonic anhydrase inhibitor (CAI) to reduce cystoid macular edema (CME).Conclusions: The efficacy of topical NSAIDs and systemic CAI association indicates that the imbalance in the distribution of retinal pigment epithelium membrane-bound carbonic anhydrase could play a major role in CME pathogenesis in GACR. To our knowledge, this is the first case of therapy with CAI treatment for GACR-related CME.
Original languageEnglish
Pages (from-to)e179-e183
Number of pages5
JournalEuropean Journal of Ophthalmology
Volume27
Publication statusPublished - 2017

All Science Journal Classification (ASJC) codes

  • Ophthalmology

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