Caffeine and cardiovascular diseases: critical review of current research

Giampiero La Rocca, Angela Zagatina, Miroslav Pohanka, Peter Kruzliak, Nazarii Kobyliak, Renee M. Smith, Alan Hayes, Hayley Loftus, Jan Novak, Giampiero La Rocca, Tawar Qaradakhi, Yoshio Uehara, Peter Kubatka, Jan Klimas, Anthony Zulli, Miroslav Soucek, Alan Hayes, Yoshio Uehara

Research output: Contribution to journalArticlepeer-review

42 Citations (Scopus)


Caffeine is a most widely consumed physiological stimulant worldwide, which is consumed via natural sources, such as coffee and tea, and now marketed sources such as energy drinks and other dietary supplements. This wide use has led to concerns regarding the safety of caffeine and its proposed beneficial role in alertness, performance and energy expenditure and side effects in the cardiovascular system. The question remains “Which dose is safe?”, as the population does not appear to adhere to the strict guidelines listed on caffeine consumption. Studies in humans and animal models yield controversial results, which can be explained by population, type and dose of caffeine and low statistical power. This review will focus on comprehensive and critical review of the current literature and provide an avenue for further study.
Original languageEnglish
Pages (from-to)1331-1343
Number of pages13
JournalEuropean Journal of Nutrition
Publication statusPublished - 2016

All Science Journal Classification (ASJC) codes

  • Medicine (miscellaneous)
  • Nutrition and Dietetics


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