Biological Properties of a Citral-Enriched Fraction of Citrus limon Essential Oil

Simona Fontana, Chiara Zichittella, Marzia Pucci, Riccardo Alessandro, Alice Conigliaro, Stefania Raimondo, Marta Moschetti, Valeria Corleone, Vincenza Tinnirello, Gioacchino Aiello, Vincenza Tinnirello, Vincenza Tinnirello

Research output: Contribution to journalArticlepeer-review


Lemon essential oil (LEO) is a well-known flavoring agent with versatile biological activities. In the present study, we have isolated and characterized four citral-enriched fractions of winter LEO. We reported that in murine and human macrophages the pre-treatment with a mix of these fractions (Cfr-LEO) reduces the expression of the pro-inflammatory cytokines TNF-α, IL-1β, and IL-6 induced by LPS. In addition, Cfr-LEO counteracts LPS-induced oxidative stress, as shown by the increase in the GSH/GSSG ratio in comparison to cells treated with LPS alone. Overall, the results reported here encourage the application of EO fractions, enriched in citral, in the nutraceutical industry, not only for its organoleptic properties but also for its protective action against inflammation and oxidative stress.
Original languageEnglish
Pages (from-to)1290-
Number of pages16
Publication statusPublished - 2020

All Science Journal Classification (ASJC) codes

  • Food Science
  • Microbiology
  • Health(social science)
  • Health Professions (miscellaneous)
  • Plant Science


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