Biodistribution of Insulin-Nanogels in Mouse: A Preliminary Study for the Treatment of Alzheimer’s Disease

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Abstract

A growing body of evidence shows that Insulin, Insulin Receptor (IR) and IRsignaling are involved in brain cognitive functions and their dysfunction isimplicated in Alzheimer’s disease (AD) neurodegeneration. Thus, administration of insulin could be a strategy for AD treatment. For this aim wehave designed, synthesized and characterized a nanogel system (NG) thathas been conjugated to insulin molecules (NG-In) to deliver the proteininto the brain, as a tool for the development of a new therapy against AD.In our preclinical study in mice, intraperitoneal injection of fluorescentlabeled NG has allowed to determine the biodistribution of NG vs time inthe whole body and its clearance through the kidneys and bladder. Furthermore, we have observed that mice injected with nanogel did not experiencestress, discomfort, nor mortalities have been recorded during the observationtime
Original languageEnglish
Number of pages1
JournalBiophysical Journal
Volume112
Publication statusPublished - 2017

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