BIODEGRADABLE AND pH-SENSITIVE HYDROGELS FOR POTENTIAL COLON-SPECIFIC DRUG DELIVERY: CHARACTERIZATION AND IN VITRO RELEASE STUDIES

Rossella Calabrese, Giovanna Pitarresi, Gaetano Giammona, Patrizia Paolicelli, Maria Antonietta Casadei

Research output: Contribution to journalArticlepeer-review

75 Citations (Scopus)

Abstract

A novel pH-sensitive and biodegradable composite hydrogel, based on a methacrylated and succinic derivative ofdextran, named Dex-MA-SA, and a methacrylated and succinic derivative of alpha,beta-poly(N-2-hydroxyethyl)-DL-aspartamide(PHEA), named PHM-SA, was produced by photocross-linking. The goal was to obtain a colonspecificdrug delivery system, exploiting both the pH-sensitive behavior and the colon-specific degradability. Thehydrogel prepared with a suitable ratio between the polysaccharide and the polyaminoacid was characterizedregarding its swelling behavior in gastrointestinal simulated conditions, chemical and enzymatic degradability,interaction with mucin, and cell compatibility on CaCo-2 cells. Moreover, 2-methoxyestradiol was chosen as amodel of anticancer drug and release studies, were performed in the absence or in the presence of dextranase andesterase. The obtained hydrogel, due to its pH-sensitive swelling and enzymatic degradability, together withmucoadhesion and cell compatibility, could be potentially useful as system for the oral treatment of coloniccancer.
Original languageEnglish
Pages (from-to)43-49
Number of pages7
JournalBiomacromolecules
Volume9
Publication statusPublished - 2008

All Science Journal Classification (ASJC) codes

  • Bioengineering
  • Biomaterials
  • Polymers and Plastics
  • Materials Chemistry

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