Benfotiamine accelerates the healing of ischaemic diabetic limbs in mice through protein kinase B/Akt-mediated potentiation of angiogenesis and inhibition of apoptosis.

Matilde Todaro, Campesi, Gloria Invernici, Gadau, Ward, Meloni, Graiani, Van Linthout, Spillmann, Costanza Emanueli, Meloni, Paolo Madeddu

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68 Citations (Scopus)

Abstract

Benfotiamine, a vitamin B1 analogue, reportedly prevents diabetic microangiopathy. The aim of this study was to evaluate whether benfotiamine is of benefit in reparative neovascularisation using a type I diabetes model of hindlimb ischaemia. We also investigated the involvement of protein kinase B (PKB)/Akt in the therapeutic effects of benfotiamine.
Original languageEnglish
Pages (from-to)405-420
Number of pages16
JournalDiabetologia
Volume49
Publication statusPublished - 2006

All Science Journal Classification (ASJC) codes

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism

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