"Baseline physical functioning status of metastatic colorectal cancer patients predicts the overall survival but not the activity of a front-line oxaliplatin-fluoropyrimidine doublet"

Sergio Palmeri, Valerio Milia, Sergio Mancarella, Rossana Casaretti, Luigi Maiorino, Claudia Sandomenico, Bruno Massidda, Antonio Avallone, Mario Roselli, Marina Licenziato, Donato Natale, Carlo Putzu, Pasquale Comella, Gianfranco Filippelli, Ettore Greco, Luca Franco, Giovanni Condemi, Giuseppe Barberis, Giacomo Vessia, Raffaella ManzoGiancarlo Di Pinto, Salvatore Tafuto, Silvana Leo, Antonio Gambardella, Michele Cannone, Lucio De Luca

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

BACKGROUND: No differences in response rate (RR), progression-free survival (PFS), overall survival (OS) and quality of life (QoL) were seen in patients randomly treated with biweekly oxaliplatin plus either fluorouracil/folinic acid or capecitabine. METHODS: We investigated the independent effect of baseline clinical characteristics and physical functioning (PF) domain on RR, PFS, and OS in 310 patients who completed the EORTC QLQ-C30 questionnaire. Multivariate analyses stratified by treatment were performed. An exploratory analysis was done by grouping patients with a PF score superior or equal to the highest quartile (n = 111), included between the highest and the lowest quartiles (n = 99), or inferior to the lowest quartile (n = 100). The relationship between these three groups and the ECOG PS was then analysed. RESULTS: At multivariate analysis, OS was negatively affected by the number of metastatic sites, the serum alkaline phosphatase, and the ECOG PS, while it was positively affected by the previous surgical resection of the primary tumour. Adding the baseline PF score, the number of disease sites (p < 0.0001), the serum alkaline phosphatase (p = 0.0057), and the PF (p = 0.0007) retained an independent significance, while the ECOG PS and the previous surgery were no longer significant. PF did not significantly affect PFS or RR. A good but not totally overlapping correlation was found between PF grouping and ECOG PS score. CONCLUSIONS: Baseline self-reported PF independently predicted the OS of patients. Assessment of QoL should be incorporated in randomised trials evaluating the management of patients with MCRC.
Original languageEnglish
Pages (from-to)50-56
Number of pages7
JournalActa Oncologica
Volume49
Publication statusPublished - 2010

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oxaliplatin
Colorectal Neoplasms
Survival
Disease-Free Survival
Alkaline Phosphatase
Multivariate Analysis
Quality of Life
Leucovorin
Serum
Fluorouracil

All Science Journal Classification (ASJC) codes

  • Hematology
  • Radiology Nuclear Medicine and imaging
  • Oncology

Cite this

"Baseline physical functioning status of metastatic colorectal cancer patients predicts the overall survival but not the activity of a front-line oxaliplatin-fluoropyrimidine doublet". / Palmeri, Sergio; Milia, Valerio; Mancarella, Sergio; Casaretti, Rossana; Maiorino, Luigi; Sandomenico, Claudia; Massidda, Bruno; Avallone, Antonio; Roselli, Mario; Licenziato, Marina; Natale, Donato; Putzu, Carlo; Comella, Pasquale; Filippelli, Gianfranco; Greco, Ettore; Franco, Luca; Condemi, Giovanni; Barberis, Giuseppe; Vessia, Giacomo; Manzo, Raffaella; Di Pinto, Giancarlo; Tafuto, Salvatore; Leo, Silvana; Gambardella, Antonio; Cannone, Michele; De Luca, Lucio.

In: Acta Oncologica, Vol. 49, 2010, p. 50-56.

Research output: Contribution to journalArticle

Palmeri, S, Milia, V, Mancarella, S, Casaretti, R, Maiorino, L, Sandomenico, C, Massidda, B, Avallone, A, Roselli, M, Licenziato, M, Natale, D, Putzu, C, Comella, P, Filippelli, G, Greco, E, Franco, L, Condemi, G, Barberis, G, Vessia, G, Manzo, R, Di Pinto, G, Tafuto, S, Leo, S, Gambardella, A, Cannone, M & De Luca, L 2010, '"Baseline physical functioning status of metastatic colorectal cancer patients predicts the overall survival but not the activity of a front-line oxaliplatin-fluoropyrimidine doublet"', Acta Oncologica, vol. 49, pp. 50-56.
Palmeri, Sergio ; Milia, Valerio ; Mancarella, Sergio ; Casaretti, Rossana ; Maiorino, Luigi ; Sandomenico, Claudia ; Massidda, Bruno ; Avallone, Antonio ; Roselli, Mario ; Licenziato, Marina ; Natale, Donato ; Putzu, Carlo ; Comella, Pasquale ; Filippelli, Gianfranco ; Greco, Ettore ; Franco, Luca ; Condemi, Giovanni ; Barberis, Giuseppe ; Vessia, Giacomo ; Manzo, Raffaella ; Di Pinto, Giancarlo ; Tafuto, Salvatore ; Leo, Silvana ; Gambardella, Antonio ; Cannone, Michele ; De Luca, Lucio. / "Baseline physical functioning status of metastatic colorectal cancer patients predicts the overall survival but not the activity of a front-line oxaliplatin-fluoropyrimidine doublet". In: Acta Oncologica. 2010 ; Vol. 49. pp. 50-56.
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abstract = "BACKGROUND: No differences in response rate (RR), progression-free survival (PFS), overall survival (OS) and quality of life (QoL) were seen in patients randomly treated with biweekly oxaliplatin plus either fluorouracil/folinic acid or capecitabine. METHODS: We investigated the independent effect of baseline clinical characteristics and physical functioning (PF) domain on RR, PFS, and OS in 310 patients who completed the EORTC QLQ-C30 questionnaire. Multivariate analyses stratified by treatment were performed. An exploratory analysis was done by grouping patients with a PF score superior or equal to the highest quartile (n = 111), included between the highest and the lowest quartiles (n = 99), or inferior to the lowest quartile (n = 100). The relationship between these three groups and the ECOG PS was then analysed. RESULTS: At multivariate analysis, OS was negatively affected by the number of metastatic sites, the serum alkaline phosphatase, and the ECOG PS, while it was positively affected by the previous surgical resection of the primary tumour. Adding the baseline PF score, the number of disease sites (p < 0.0001), the serum alkaline phosphatase (p = 0.0057), and the PF (p = 0.0007) retained an independent significance, while the ECOG PS and the previous surgery were no longer significant. PF did not significantly affect PFS or RR. A good but not totally overlapping correlation was found between PF grouping and ECOG PS score. CONCLUSIONS: Baseline self-reported PF independently predicted the OS of patients. Assessment of QoL should be incorporated in randomised trials evaluating the management of patients with MCRC.",
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TY - JOUR

T1 - "Baseline physical functioning status of metastatic colorectal cancer patients predicts the overall survival but not the activity of a front-line oxaliplatin-fluoropyrimidine doublet"

AU - Palmeri, Sergio

AU - Milia, Valerio

AU - Mancarella, Sergio

AU - Casaretti, Rossana

AU - Maiorino, Luigi

AU - Sandomenico, Claudia

AU - Massidda, Bruno

AU - Avallone, Antonio

AU - Roselli, Mario

AU - Licenziato, Marina

AU - Natale, Donato

AU - Putzu, Carlo

AU - Comella, Pasquale

AU - Filippelli, Gianfranco

AU - Greco, Ettore

AU - Franco, Luca

AU - Condemi, Giovanni

AU - Barberis, Giuseppe

AU - Vessia, Giacomo

AU - Manzo, Raffaella

AU - Di Pinto, Giancarlo

AU - Tafuto, Salvatore

AU - Leo, Silvana

AU - Gambardella, Antonio

AU - Cannone, Michele

AU - De Luca, Lucio

PY - 2010

Y1 - 2010

N2 - BACKGROUND: No differences in response rate (RR), progression-free survival (PFS), overall survival (OS) and quality of life (QoL) were seen in patients randomly treated with biweekly oxaliplatin plus either fluorouracil/folinic acid or capecitabine. METHODS: We investigated the independent effect of baseline clinical characteristics and physical functioning (PF) domain on RR, PFS, and OS in 310 patients who completed the EORTC QLQ-C30 questionnaire. Multivariate analyses stratified by treatment were performed. An exploratory analysis was done by grouping patients with a PF score superior or equal to the highest quartile (n = 111), included between the highest and the lowest quartiles (n = 99), or inferior to the lowest quartile (n = 100). The relationship between these three groups and the ECOG PS was then analysed. RESULTS: At multivariate analysis, OS was negatively affected by the number of metastatic sites, the serum alkaline phosphatase, and the ECOG PS, while it was positively affected by the previous surgical resection of the primary tumour. Adding the baseline PF score, the number of disease sites (p < 0.0001), the serum alkaline phosphatase (p = 0.0057), and the PF (p = 0.0007) retained an independent significance, while the ECOG PS and the previous surgery were no longer significant. PF did not significantly affect PFS or RR. A good but not totally overlapping correlation was found between PF grouping and ECOG PS score. CONCLUSIONS: Baseline self-reported PF independently predicted the OS of patients. Assessment of QoL should be incorporated in randomised trials evaluating the management of patients with MCRC.

AB - BACKGROUND: No differences in response rate (RR), progression-free survival (PFS), overall survival (OS) and quality of life (QoL) were seen in patients randomly treated with biweekly oxaliplatin plus either fluorouracil/folinic acid or capecitabine. METHODS: We investigated the independent effect of baseline clinical characteristics and physical functioning (PF) domain on RR, PFS, and OS in 310 patients who completed the EORTC QLQ-C30 questionnaire. Multivariate analyses stratified by treatment were performed. An exploratory analysis was done by grouping patients with a PF score superior or equal to the highest quartile (n = 111), included between the highest and the lowest quartiles (n = 99), or inferior to the lowest quartile (n = 100). The relationship between these three groups and the ECOG PS was then analysed. RESULTS: At multivariate analysis, OS was negatively affected by the number of metastatic sites, the serum alkaline phosphatase, and the ECOG PS, while it was positively affected by the previous surgical resection of the primary tumour. Adding the baseline PF score, the number of disease sites (p < 0.0001), the serum alkaline phosphatase (p = 0.0057), and the PF (p = 0.0007) retained an independent significance, while the ECOG PS and the previous surgery were no longer significant. PF did not significantly affect PFS or RR. A good but not totally overlapping correlation was found between PF grouping and ECOG PS score. CONCLUSIONS: Baseline self-reported PF independently predicted the OS of patients. Assessment of QoL should be incorporated in randomised trials evaluating the management of patients with MCRC.

KW - metastatic colorectal cancer,oxaliplatin, physical functioning status

UR - http://hdl.handle.net/10447/46774

M3 - Article

VL - 49

SP - 50

EP - 56

JO - Acta Oncologica

JF - Acta Oncologica

SN - 0284-186X

ER -