B cells and immunosenescence: a focus on IgG+IgD-CD27- (DN) Bcells in aged humans.

Matteo Bulati, Giuseppina Candore, Calogero Caruso, Giuseppina Colonna Romano, Yu-Chang Wu, Deborah K. Dunn-Walters, Silvio Buffa, Mariavaleria Pellicano'

Research output: Contribution to journalArticlepeer-review

52 Citations (Scopus)

Abstract

Immunosenescence contributes to the decreased ability of the elderly to controlinfectious diseases, which is also reflected in their generally poor response to new antigens and vaccination. It is known that the T cell branch of the immunesystem is impaired in the elderly mainly due to expansion of memory/effectorcells that renders the immune system less able to respond to new antigens. Blymphocytes are also impaired in the elderly in terms of their response to newantigens. In this paper we review recent work on B cell immunosenescence focusingour attention on memory B cells and a subset of memory B cells (namelyIgG(+)IgD(-)CD27(-)) that we have demonstrated is increased in healthy elderly.
Original languageEnglish
Pages (from-to)274-284
Number of pages11
JournalAgeing Research Reviews
Volume10
Publication statusPublished - 2011

All Science Journal Classification (ASJC) codes

  • Biotechnology
  • Biochemistry
  • Ageing
  • Molecular Biology
  • Neurology

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