Atrial natriuretic peptide (ANP) and oxytocin-expression in the adult and mouse cerebellum

Aldo Gerbino, Elvira Vittoria Farina, Alessio Lipari, Luana Lipari

Research output: Contribution to journalArticlepeer-review

Abstract

AbstractBackground: Many studies are in the literature on the ANP and oxytocin-presence in the brain, but very few studieswith controversial results are reported on the presence of these peptides in the cerebellum. This immunohistochemicalstudy investigates on the ANP and oxytocin-presence in the cerebellum of the adult rat and mouse rodents.Results: This study, firstly, evidences the ANP- immunopositivity in cerebellar cortex of both rat and mouse rodents. Inrat the molecular layer presents some few immunopositive fibers, but no neuron resulted immunopositive; thegranular and Purkinje cells are immunopositive. In mouse the cerebellar cortex ANP-immunopositivity is present in alllayers. The oxytocin-presence in the rat the afferent fibers are immunopositive are in the granular layer; in mouse theOT-immunopositivity is in the molecular layer only.Conclusions: This study, firstly, shows that ANP and OT are present in the cerebellar cortex both in rat and mouserodents. In the mouse cerebellar cortex ANP-presence is more diffuse and OT- localization differences in the two species.
Original languageEnglish
Number of pages4
JournalCEREBELLUM & ATAXIAS
Volume2
Publication statusPublished - 2015

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