Asymptomatic carotid lesions add to cardiovascular risk prediction

Salvatore Novo, Egle Corrado, Giuseppina Novo, Gisella R. Amoroso, Claudia L. Visconti, Luciana D'Angelo, Monica Lunetta, Giovanni Fazio, Salvatore Novo, Giuseppina Novo, Rosalba Tantillo, Egle Corrado, Ida Muratori, Claudia Luisa Visconti, Gisella Rita Amoroso, Ida Maria Muratori, Luciana D'Angelo, Monica Lunetta

Research output: Contribution to journalArticlepeer-review

24 Citations (Scopus)


To show that subclinical atherosclerosis (subclinical-ATS) of carotid arteries [intima–media thickness (IMT) or asymptomatic carotid plaque (ACP)], may provide additional information for risk stratification, in asymptomatic patients, aged greater than 45 years, with a cluster of risk factors (RFs). We studied 558 asymptomatic patients (235 males). RFs for atherosclerosis were assessed and the 10-year-risk was calculated according to the Italian risk score. Doppler ultrasound of carotid arteries identified the presence of IMT greater than 0.9 mm in 183 patients and ACP in 147 patients. One hundred and fifty-three patients developed cerebrovascular or cardiovascular (CV) events in the follow-up: 67 developed acute myocardial infarction, 39 developed angina, 25 had a stroke or transient ischemic attack, six died for CV events, and 16 underwent percutaneous or surgical revascularization. The incidence reflected the different risk profiles (4,14, and 20%, respectively). However, in patients with baseline subclinical-ATS the incidence of events increased to 35, 46, and 63%, respectively. In the multivariate analysis the incidence of events was significantly influenced by the presence of asymptomatic carotid lesions in each risk category. In our experience, the incidence of CV events is enhanced in patients with subclinical-ATS. Increased IMT and ACP predict CV events and improve the risk stratification of asymptomatic patients aged greater than 45 years and with a cluster of RFs, in a long-term follow-up
Original languageEnglish
Pages (from-to)514-518
Number of pages5
Publication statusPublished - 2010

All Science Journal Classification (ASJC) codes

  • Epidemiology
  • Cardiology and Cardiovascular Medicine


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