TY - JOUR
T1 - Asymptomatic carotid lesions add to cardiovascular risk prediction
AU - Novo, Salvatore
AU - Corrado, Egle
AU - Novo, Giuseppina
AU - Amoroso, Gisella R.
AU - Visconti, Claudia L.
AU - D'Angelo, Luciana
AU - Lunetta, Monica
AU - Fazio, Giovanni
AU - Novo, Salvatore
AU - Novo, Giuseppina
AU - Tantillo, Rosalba
AU - Corrado, Egle
AU - Muratori, Ida
AU - Visconti, Claudia Luisa
AU - Amoroso, Gisella Rita
AU - Muratori, Ida Maria
AU - D'Angelo, Luciana
AU - Lunetta, Monica
PY - 2010
Y1 - 2010
N2 - To show that subclinical atherosclerosis (subclinical-ATS) of carotid arteries [intima–media thickness (IMT) or asymptomatic carotid plaque (ACP)], may provide additional information for risk stratification, in asymptomatic patients, aged greater than 45 years, with a cluster of risk factors (RFs). We studied 558 asymptomatic patients (235 males). RFs for atherosclerosis were assessed and the 10-year-risk was calculated according to the Italian risk score. Doppler ultrasound of carotid arteries identified the presence of IMT greater than 0.9 mm in 183 patients and ACP in 147 patients. One hundred and fifty-three patients developed cerebrovascular or cardiovascular (CV) events in the follow-up: 67 developed acute myocardial infarction, 39 developed angina, 25 had a stroke or transient ischemic attack, six died for CV events, and 16 underwent percutaneous or surgical revascularization. The incidence reflected the different risk profiles (4,14, and 20%, respectively). However, in patients with baseline subclinical-ATS the incidence of events increased to 35, 46, and 63%, respectively. In the multivariate analysis the incidence of events was significantly influenced by the presence of asymptomatic carotid lesions in each risk category. In our experience, the incidence of CV events is enhanced in patients with subclinical-ATS. Increased IMT and ACP predict CV events and improve the risk stratification of asymptomatic patients aged greater than 45 years and with a cluster of RFs, in a long-term follow-up
AB - To show that subclinical atherosclerosis (subclinical-ATS) of carotid arteries [intima–media thickness (IMT) or asymptomatic carotid plaque (ACP)], may provide additional information for risk stratification, in asymptomatic patients, aged greater than 45 years, with a cluster of risk factors (RFs). We studied 558 asymptomatic patients (235 males). RFs for atherosclerosis were assessed and the 10-year-risk was calculated according to the Italian risk score. Doppler ultrasound of carotid arteries identified the presence of IMT greater than 0.9 mm in 183 patients and ACP in 147 patients. One hundred and fifty-three patients developed cerebrovascular or cardiovascular (CV) events in the follow-up: 67 developed acute myocardial infarction, 39 developed angina, 25 had a stroke or transient ischemic attack, six died for CV events, and 16 underwent percutaneous or surgical revascularization. The incidence reflected the different risk profiles (4,14, and 20%, respectively). However, in patients with baseline subclinical-ATS the incidence of events increased to 35, 46, and 63%, respectively. In the multivariate analysis the incidence of events was significantly influenced by the presence of asymptomatic carotid lesions in each risk category. In our experience, the incidence of CV events is enhanced in patients with subclinical-ATS. Increased IMT and ACP predict CV events and improve the risk stratification of asymptomatic patients aged greater than 45 years and with a cluster of RFs, in a long-term follow-up
KW - cardiovascular risk
KW - carotid
KW - lesions
KW - cardiovascular risk
KW - carotid
KW - lesions
UR - http://hdl.handle.net/10447/237854
M3 - Article
SN - 1741-8267
VL - 17
SP - 514
EP - 518
JO - EUROPEAN JOURNAL OF CARDIOVASCULAR PREVENTION & REHABILITATION
JF - EUROPEAN JOURNAL OF CARDIOVASCULAR PREVENTION & REHABILITATION
ER -