ASSOCIAZIONE TRA INDICE DI RESISTENZA INTRARENALE ESTIFFNESS AORTICA IN SOGGETTI CON MALATTIARENALE CRONICA

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Abstract

[automatically translated] RATIONAL. The intraparenchymal renal resistance index (RI), as assessed by echo-color Doppler, was classically used as a valuable diagnostic tool and prognostic evaluation of renal disease. Recent studies suggest that intrarenal hemodynamic parameters, and IR in particular, can also be associated with systemic vascular alterations, and an increase in cardiovascular risk. However, there are conflicting data in the literature about the independent association between IR and aortic pulse wave velocity (PWVa), arterial stiffness index, as well as an expression of subclinical organ damage. The aim of this study was therefore to evaluate the relationship between IR and PWVa in a population of patients with arterial hypertension and chronic kidney disease (stages G1-G4 KDOQI). CASES AND METHODS. They were therefore enrolled 124 subjects, aged between 30 and 70 years, consecutively referred to our center of Hypertension. They were excluded from the study patients with renovascular hypertension, endocrine or with end-stage renal disease (G5 stage KDOQI). All patients underwent echo-color-Doppler of intrarenal vessels for evaluating hemodynamic parameters intraparenchymal. The Doppler signal is obtained at the level of the cortico-medullary junction, in correspondence of the interlobar arteries. The IR was calculated as the average of six measurements (three for each kidney). The PWVa was measured by computerized Oscillometric method (arteriograph). The GFR was estimated CKD-EPI equation. RESULTS. Patients with PWVa> 10 m / sec showed higher values of IR than subjects with PWVa <10 m / sec (0.67 vs 0.63 + 0:06 + 0:08; p = 0.01). In addition, a statistically significant correlation was observed between IR and PWVa (r = 0.350, p <0.001), and this correlation was maintained even after adjusting for various confounding factors. CONCLUSIONS. Our results, showing a strong independent association between IR and kidney PWVa, seem to confirm that the IR can be considered a marker of systemic vascular changes and therefore also a cardiovascular risk predictor. and this correlation was maintained even after adjusting for various confounding factors. CONCLUSIONS. Our results, showing a strong independent association between IR and kidney PWVa, seem to confirm that the IR can be considered a marker of systemic vascular changes and therefore also a cardiovascular risk predictor. and this correlation was maintained even after adjusting for various confounding factors. CONCLUSIONS. Our results, showing a strong independent association between IR and kidney PWVa, seem to confirm that the IR can be considered a marker of systemic vascular changes and therefore also a cardiovascular risk predictor.
Original languageItalian
Pages177-177
Number of pages1
Publication statusPublished - 2014

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