Association of Oxidative Stress with Aortic Stiffness in Hypertensive Patients with Chronic Kidney Disease

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Abstract

Several studies have consistently demonstrated that arterial stiffness becomesprogressively worse as CKD progresses and a negative correlation of oxidative stress withrenal function has been described. There is also sound experimental evidence indicating thatoxidative stress is involved in atherogenesis. The contribution of oxidative stress to aortic stiffnessis less clear.Aim: To analyse the relationship between plasma levels of 8-ISO-prostaglandin F2alpha (8-ISOPGF2alpha),an index of lipid peroxidation, considered a reliable biomarker of oxidative stress,and aortic stiffness in a group of hypertensive patients with chronic kidney disease.Methods: We enrolled 126 hypertensive patients (mean age 58 – 13 years, males 56%) with CKD.In all the subjects 24-hour urine collection was performed to determine albuminuria and routinebiochemical parameters and 8-ISO-PGF2alpha plasma values, measured by an enzyme-linkedimmunosorbent assay, were obtained. Moreover, ambulatory blood pressure monitoring andmeasurement of c-f PWV, by a computerized automatic method (Arteriograph), were performed.The GFR was estimated by the four-variable MDRD study equation.Results: The mean value of eGFR was 44 – 26mL/min/1.73m2). The patients with elevated valuesof c-f PWV (>12m/sec) showed significantly higher 8-ISO-PGF2alpha plasma levels than those ofsubjects with PWV <12m/sec (p < 0.01). A statistical significant correlation was found between8-ISO-PGF2alpha and c-fPWVin the whole study population (r = 0.33; p = 0.001). This associationheld even after adjustment for age, gender, mean arterial pressure, smoking habit, glycaemia, totalcholesterol, calcium phosphate product and eGFR (beta = 0.23; p = 0.006) in a stepwise multipleregression model.Conclusions: Our results seem to suggest that in hypertensive subjects with CKD there is anindependent relationship between oxidative stress and aortic stiffness and that the unfavourableinfluence of a reduced renal function on large artery elastic properties may be partly mediated byan increased oxidative stress.
Original languageEnglish
Number of pages1
Publication statusPublished - 2011

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