Association of Klotho polymorphisms with healthy aging: a systematic review andmeta-analysis.

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Abstract

Today it is clearly evident that genetic background constitutes an integral part of aging and longevity. Many studies on long-lived people have been conductedemphasizing the role of certain genes in long life. Classic case-control studies,genome-wide association studies, and high-throughput sequencing have permittedidentification of a variety of genetic variants seemingly associated withlongevity. Over the years, aging research has focused on the insulin/insulin-likegrowth factor-1 (IGF-1) signaling pathway because of its evolutionarily conservedcorrelation with life-span extension in model animals. Indeed, manysingle-nucleotide polymorphisms (SNPs) associated with longevity were identified in genes encoding proteins that take part in this metabolic pathway. Closelyrelated to this pathway is the Klotho gene. It encodes a type-I membrane protein expressed in two forms, membrane and secreted. The latter form suppressesoxidative stress and growth factor signaling and regulates ion channels andtransporters. In particular, its over-expression seems to be able to suppressinsulin/IGF-1 signaling extending life span. Thus, our aim was to assemble theresults in the literature concerning the association between the functionalvariant of the Klotho "KL-VS" stretch, which contains six polymorphisms inlinkage disequilibrium, and successful aging to quantify the possible effect ofthe variants. The results of our systematic review indicate that the Klotho KL-VSvariant is associated with healthy aging.
Original languageEnglish
Pages (from-to)212-216
Number of pages5
JournalRejuvenation Research
Volume17
Publication statusPublished - 2014

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All Science Journal Classification (ASJC) codes

  • Ageing
  • Geriatrics and Gerontology

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