Assessment of atrial diastolic function in patients with hypertrophic cardiomyopathy by cine magnetic resonance imaging

Massimo Galia, Ludovico La Grutta, Massimo Midiri, Patrizia Toia, Alessia Pepe, Giovanni Donato Aquaro, Giancarlo Todiere, Giovanni D. Gentile, Emanuele Grassedonio

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Abstract

Purpose: This study was conducted to assess the role of atrial function by cardiac magnetic resonance (CMR) for the evaluation of diastolic physiology in patients with hypertrophic cardiomyopathy (HCM) compared to healthy controls. Materials and methods: We enrolled 23 consecutive patients affected by HCM and 43 healthy subjects as age-matched control cases (CC). CMR was performed through acquisition of cine steady-state free precession sequences using a 1.5-T scanner. Image postprocessing was carried out using Tracking Tool software. Results: Atrial volumes were significantly higher in patients with HCM compared to CC: maximum atrial volume (p = 0.007) and minimum atrial volume (p = 0.01). A statistically significant difference was also observed in atrial ejection fraction in patients with HCM (p < 0.0001). The atrial volume curves defined as cavity volume over time (dV/t) showed significant differences: early atrial peak emptying rate (PERE) (maximum rate of emptying independent of atrial contraction) in HCM was −146 ± 53 ml/s versus −227 ± 86 ml/s in CC (p < 0.0001); active atrial peak emptying rate (PERA) (maximum rate of emptying secondary to atrial contraction) in HCM was −256 ± 80 ml/s versus −216 ± 104 ml/s in CC (p = 0.05); the atrial PER E/A ratio in HCM was 0.6 ± 0.2 versus 1.05 ± 0.5 in CC (p < 0.0001). Conclusions: This study demonstrated that in HCM patients with early diastolic dysfunction the parameters of left atrial function assessed by CMR are impaired before the ventricular diastolic indexes such as the early peak filling rate and the active peak filling rate.
Original languageEnglish
Pages (from-to)714-722
Number of pages9
JournalLA RADIOLOGIA MEDICA
Volume120
Publication statusPublished - 2015

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Atrial Function
Cine Magnetic Resonance Imaging
Hypertrophic Cardiomyopathy
Magnetic Resonance Spectroscopy
Left Atrial Function
Healthy Volunteers
Software

All Science Journal Classification (ASJC) codes

  • Radiology Nuclear Medicine and imaging

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Assessment of atrial diastolic function in patients with hypertrophic cardiomyopathy by cine magnetic resonance imaging. / Galia, Massimo; La Grutta, Ludovico; Midiri, Massimo; Toia, Patrizia; Pepe, Alessia; Aquaro, Giovanni Donato; Todiere, Giancarlo; Gentile, Giovanni D.; Grassedonio, Emanuele.

In: LA RADIOLOGIA MEDICA, Vol. 120, 2015, p. 714-722.

Research output: Contribution to journalArticle

Galia, Massimo ; La Grutta, Ludovico ; Midiri, Massimo ; Toia, Patrizia ; Pepe, Alessia ; Aquaro, Giovanni Donato ; Todiere, Giancarlo ; Gentile, Giovanni D. ; Grassedonio, Emanuele. / Assessment of atrial diastolic function in patients with hypertrophic cardiomyopathy by cine magnetic resonance imaging. In: LA RADIOLOGIA MEDICA. 2015 ; Vol. 120. pp. 714-722.
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abstract = "Purpose: This study was conducted to assess the role of atrial function by cardiac magnetic resonance (CMR) for the evaluation of diastolic physiology in patients with hypertrophic cardiomyopathy (HCM) compared to healthy controls. Materials and methods: We enrolled 23 consecutive patients affected by HCM and 43 healthy subjects as age-matched control cases (CC). CMR was performed through acquisition of cine steady-state free precession sequences using a 1.5-T scanner. Image postprocessing was carried out using Tracking Tool software. Results: Atrial volumes were significantly higher in patients with HCM compared to CC: maximum atrial volume (p = 0.007) and minimum atrial volume (p = 0.01). A statistically significant difference was also observed in atrial ejection fraction in patients with HCM (p < 0.0001). The atrial volume curves defined as cavity volume over time (dV/t) showed significant differences: early atrial peak emptying rate (PERE) (maximum rate of emptying independent of atrial contraction) in HCM was −146 ± 53 ml/s versus −227 ± 86 ml/s in CC (p < 0.0001); active atrial peak emptying rate (PERA) (maximum rate of emptying secondary to atrial contraction) in HCM was −256 ± 80 ml/s versus −216 ± 104 ml/s in CC (p = 0.05); the atrial PER E/A ratio in HCM was 0.6 ± 0.2 versus 1.05 ± 0.5 in CC (p < 0.0001). Conclusions: This study demonstrated that in HCM patients with early diastolic dysfunction the parameters of left atrial function assessed by CMR are impaired before the ventricular diastolic indexes such as the early peak filling rate and the active peak filling rate.",
author = "Massimo Galia and {La Grutta}, Ludovico and Massimo Midiri and Patrizia Toia and Alessia Pepe and Aquaro, {Giovanni Donato} and Giancarlo Todiere and Gentile, {Giovanni D.} and Emanuele Grassedonio",
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T1 - Assessment of atrial diastolic function in patients with hypertrophic cardiomyopathy by cine magnetic resonance imaging

AU - Galia, Massimo

AU - La Grutta, Ludovico

AU - Midiri, Massimo

AU - Toia, Patrizia

AU - Pepe, Alessia

AU - Aquaro, Giovanni Donato

AU - Todiere, Giancarlo

AU - Gentile, Giovanni D.

AU - Grassedonio, Emanuele

PY - 2015

Y1 - 2015

N2 - Purpose: This study was conducted to assess the role of atrial function by cardiac magnetic resonance (CMR) for the evaluation of diastolic physiology in patients with hypertrophic cardiomyopathy (HCM) compared to healthy controls. Materials and methods: We enrolled 23 consecutive patients affected by HCM and 43 healthy subjects as age-matched control cases (CC). CMR was performed through acquisition of cine steady-state free precession sequences using a 1.5-T scanner. Image postprocessing was carried out using Tracking Tool software. Results: Atrial volumes were significantly higher in patients with HCM compared to CC: maximum atrial volume (p = 0.007) and minimum atrial volume (p = 0.01). A statistically significant difference was also observed in atrial ejection fraction in patients with HCM (p < 0.0001). The atrial volume curves defined as cavity volume over time (dV/t) showed significant differences: early atrial peak emptying rate (PERE) (maximum rate of emptying independent of atrial contraction) in HCM was −146 ± 53 ml/s versus −227 ± 86 ml/s in CC (p < 0.0001); active atrial peak emptying rate (PERA) (maximum rate of emptying secondary to atrial contraction) in HCM was −256 ± 80 ml/s versus −216 ± 104 ml/s in CC (p = 0.05); the atrial PER E/A ratio in HCM was 0.6 ± 0.2 versus 1.05 ± 0.5 in CC (p < 0.0001). Conclusions: This study demonstrated that in HCM patients with early diastolic dysfunction the parameters of left atrial function assessed by CMR are impaired before the ventricular diastolic indexes such as the early peak filling rate and the active peak filling rate.

AB - Purpose: This study was conducted to assess the role of atrial function by cardiac magnetic resonance (CMR) for the evaluation of diastolic physiology in patients with hypertrophic cardiomyopathy (HCM) compared to healthy controls. Materials and methods: We enrolled 23 consecutive patients affected by HCM and 43 healthy subjects as age-matched control cases (CC). CMR was performed through acquisition of cine steady-state free precession sequences using a 1.5-T scanner. Image postprocessing was carried out using Tracking Tool software. Results: Atrial volumes were significantly higher in patients with HCM compared to CC: maximum atrial volume (p = 0.007) and minimum atrial volume (p = 0.01). A statistically significant difference was also observed in atrial ejection fraction in patients with HCM (p < 0.0001). The atrial volume curves defined as cavity volume over time (dV/t) showed significant differences: early atrial peak emptying rate (PERE) (maximum rate of emptying independent of atrial contraction) in HCM was −146 ± 53 ml/s versus −227 ± 86 ml/s in CC (p < 0.0001); active atrial peak emptying rate (PERA) (maximum rate of emptying secondary to atrial contraction) in HCM was −256 ± 80 ml/s versus −216 ± 104 ml/s in CC (p = 0.05); the atrial PER E/A ratio in HCM was 0.6 ± 0.2 versus 1.05 ± 0.5 in CC (p < 0.0001). Conclusions: This study demonstrated that in HCM patients with early diastolic dysfunction the parameters of left atrial function assessed by CMR are impaired before the ventricular diastolic indexes such as the early peak filling rate and the active peak filling rate.

UR - http://hdl.handle.net/10447/203906

UR - http://link.springer.com/journal/11547

M3 - Article

VL - 120

SP - 714

EP - 722

JO - LA RADIOLOGIA MEDICA

JF - LA RADIOLOGIA MEDICA

SN - 0033-8362

ER -