Assessing chronological aging in Saccharomyces cerevisiae

Mario Giuseppe Mirisola, Min Wei, Jia Hu, Valter D. Longo

Research output: Chapter in Book/Report/Conference proceedingChapter

32 Citations (Scopus)


Saccharomyces cerevisiae is one of the most studied model organisms for the identification of genes and mechanisms that affect aging. The chronological lifespan (CLS) assay, which monitors the survival of a non-dividing population, is one of the two methods to study aging in yeast. To eliminate potential artifacts and identify genes and signaling pathways that may also affect aging in higher eukaryotes, it is important to determine CLS by multiple methods. Here, we describe these methods as well as the assays to study macromolecular damage during aging in yeast, with a focus on genomic instability.
Original languageEnglish
Title of host publicationAssessing chronological aging in Saccharomyces cerevisiae
Number of pages10
Publication statusPublished - 2013

Publication series


All Science Journal Classification (ASJC) codes

  • Molecular Biology
  • Genetics


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