Application of an immunoproteomic approach to detect anti-profilin antibodies in sera of paritaria judaica allergic patients

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Pollen from grasses, weeds, and trees constitutes one of the main sources of inhalant allergens frequently associated with seasonal patterns of allergic diseases. Pollen allergens show some analogies in the amino acids sequence which determine immunological similarity and cross reactivity. Parietaria judaica (P.j) pollen represents one of the main sources of allergens in the Mediterranean area and its major allergens have already been identified (Par j 1 and Par j 2). Recently, has been also described a minor allergen, profilin (Par j 3), an allergen present in pollen of trees, grasses and weeds. Allergenic plant profilins constitute a highly conserved family with sequence identities of 70% to 85% responsible for a wide range of cross-reactivity among pollens and plant foods. In this work we use an immunoproteomic approach to detect IgE antibodies against profilin in serum of P.j allergic patients.
Original languageEnglish
Title of host publicationApplication of an immunoproteomic approach to detect anti-profilin antibodies in sera of paritaria judaica allergic patients
Pages69-74
Number of pages6
Publication statusPublished - 2011

Publication series

NameIn “Medical Biotechnologies and Forensic Medicine Reviews.

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