Antispasmodic effects and structure-activity relationships of labdane diterpenoids from Marrubium globosum ssp. libanoticum

Sergio Rosselli, Maurizio Bruno, Francesca Borrelli, Angelo A. Izzo, Daniela Rigano, Felice Senatore, Raffaele Capasso, Gabriella Aviello, Carmen Formisano

Research output: Contribution to journalArticlepeer-review

30 Citations (Scopus)

Abstract

Marrubium globosum ssp. libanoticum is a medicinal plant used in Lebanon to reduce pain and smooth muscle spasms.A chloroform extract obtained from M. globosum aerial parts reduced acetylcholine-induced contractions in the isolated mouse ileum. The purification of this extract identified, among 12 isolated labdane diterpenoids, four new compounds, named 13-epicyllenin A (4), 13,15-diepicyllenin A (5), marrulibacetal (9), and marrulactone (11). Their structures were determined by spectroscopic methods. Compound 9, which exerted antispasmodic activity, is likely the active ingredient of the extract. Preliminary structure-activity relationships for this class of compounds are suggested.
Original languageEnglish
Pages (from-to)1477-1481
Number of pages5
JournalJournal of Natural Products
Volume72
Publication statusPublished - 2009

All Science Journal Classification (ASJC) codes

  • Analytical Chemistry
  • Molecular Medicine
  • Pharmacology
  • Pharmaceutical Science
  • Drug Discovery
  • Complementary and alternative medicine
  • Organic Chemistry

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