Antiproliferative Oleanane Saponins from Meryta denhamii

Fabio Venturella, Francesco De Simone, Nunziatina De Tommasi, Francesco De Simone, Fabrizio Dal Piaz, Paolo De Caprariis, Giuseppina Cioffi, Antonio Vassallo, Antonio Vassallo

Research output: Contribution to journalArticlepeer-review

22 Citations (Scopus)

Abstract

Eight new oleanane saponins (1- 8) together with four know saponins (9-12) were isolated from the aerial parts of Meryta denhamii. Their structures were elucidated by 1D and 2D NMR experiments including 1D TOCSY, DQF-COSY, ROESY, HSQC, and HMBC spectroscopy, as well as ESIMS analysis. The antiproliferative activity of all compounds was evaluated using three murine and human cancer cell lines: J774.A1, HEK-293, and WEHI-164.
Original languageEnglish
Pages (from-to)1000-1004
Number of pages4
JournalJournal of Natural Products
Volume71
Publication statusPublished - 2008

All Science Journal Classification (ASJC) codes

  • Analytical Chemistry
  • Molecular Medicine
  • Pharmacology
  • Pharmaceutical Science
  • Drug Discovery
  • Complementary and alternative medicine
  • Organic Chemistry

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