Antiproliferative Oleanane Saponins from Meryta denhamii

Fabio Venturella; Francesco De Simone; Nunziatina De Tommasi; Francesco De Simone; Fabrizio Dal Piaz; Paolo De Caprariis; Giuseppina Cioffi; Antonio Vassallo; Antonio Vassallo

Antiproliferative Oleanane Saponins from Meryta denhamii

Fabio Venturella, Francesco De Simone, Nunziatina De Tommasi, Francesco De Simone, Fabrizio Dal Piaz, Paolo De Caprariis, Giuseppina Cioffi, Antonio Vassallo, Antonio Vassallo

Research output: Contribution to journal › Article › peer-review

22 Citations (Scopus)

Abstract

Eight new oleanane saponins (1- 8) together with four know saponins (9-12) were isolated from the aerial parts of Meryta denhamii. Their structures were elucidated by 1D and 2D NMR experiments including 1D TOCSY, DQF-COSY, ROESY, HSQC, and HMBC spectroscopy, as well as ESIMS analysis. The antiproliferative activity of all compounds was evaluated using three murine and human cancer cell lines: J774.A1, HEK-293, and WEHI-164.

Original language	English
Pages (from-to)	1000-1004
Number of pages	4
Journal	Journal of Natural Products
Volume	71
Publication status	Published - 2008

All Science Journal Classification (ASJC) codes

Analytical Chemistry
Molecular Medicine
Pharmacology
Pharmaceutical Science
Drug Discovery
Complementary and alternative medicine
Organic Chemistry

Cite this

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title = "Antiproliferative Oleanane Saponins from Meryta denhamii",

abstract = "Eight new oleanane saponins (1- 8) together with four know saponins (9-12) were isolated from the aerial parts of Meryta denhamii. Their structures were elucidated by 1D and 2D NMR experiments including 1D TOCSY, DQF-COSY, ROESY, HSQC, and HMBC spectroscopy, as well as ESIMS analysis. The antiproliferative activity of all compounds was evaluated using three murine and human cancer cell lines: J774.A1, HEK-293, and WEHI-164.",

keywords = "Antiproliferative effects, Oleanane Saponins, Antiproliferative effects, Oleanane Saponins",

author = "Fabio Venturella and {De Simone}, Francesco and {De Tommasi}, Nunziatina and {De Simone}, Francesco and {Dal Piaz}, Fabrizio and {De Caprariis}, Paolo and Giuseppina Cioffi and Antonio Vassallo and Antonio Vassallo",

year = "2008",

language = "English",

volume = "71",

pages = "1000--1004",

journal = "Journal of Natural Products",

issn = "0163-3864",

publisher = "American Chemical Society",

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TY - JOUR

T1 - Antiproliferative Oleanane Saponins from Meryta denhamii

AU - Venturella, Fabio

AU - De Simone, Francesco

AU - De Tommasi, Nunziatina

AU - De Simone, Francesco

AU - Dal Piaz, Fabrizio

AU - De Caprariis, Paolo

AU - Cioffi, Giuseppina

AU - Vassallo, Antonio

PY - 2008

Y1 - 2008

N2 - Eight new oleanane saponins (1- 8) together with four know saponins (9-12) were isolated from the aerial parts of Meryta denhamii. Their structures were elucidated by 1D and 2D NMR experiments including 1D TOCSY, DQF-COSY, ROESY, HSQC, and HMBC spectroscopy, as well as ESIMS analysis. The antiproliferative activity of all compounds was evaluated using three murine and human cancer cell lines: J774.A1, HEK-293, and WEHI-164.

AB - Eight new oleanane saponins (1- 8) together with four know saponins (9-12) were isolated from the aerial parts of Meryta denhamii. Their structures were elucidated by 1D and 2D NMR experiments including 1D TOCSY, DQF-COSY, ROESY, HSQC, and HMBC spectroscopy, as well as ESIMS analysis. The antiproliferative activity of all compounds was evaluated using three murine and human cancer cell lines: J774.A1, HEK-293, and WEHI-164.

KW - Antiproliferative effects

KW - Oleanane Saponins

KW - Antiproliferative effects

KW - Oleanane Saponins

UR - http://hdl.handle.net/10447/38990

M3 - Article

VL - 71

SP - 1000

EP - 1004

JO - Journal of Natural Products

JF - Journal of Natural Products

SN - 0163-3864

ER -

Antiproliferative Oleanane Saponins from Meryta denhamii

Abstract

All Science Journal Classification (ASJC) codes

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