Antioxidant Betalains from Cactus Pear (Opuntia Ficus Indica) inhibit endothelial ICAM-1 expression

Maria Antonia Livrea; Luisa Tesoriere; Carla Gentile; Mario Allegra; null D'Alessio

Antioxidant Betalains from Cactus Pear (Opuntia Ficus Indica) inhibit endothelial ICAM-1 expression

Maria Antonia Livrea, Luisa Tesoriere, Carla Gentile, Mario Allegra, D'Alessio

Scienze e Tecnologie Biologiche Chimiche e Farmaceutiche

Research output: Contribution to journal › Article › peer-review

141 Citations (Scopus)

Abstract

It has been suggested that some pigments would have antioxidantproperties and that their presence in dietary constituents would contribute toreduce the risk of oxidative stress–correlated diseases. Among others, inflammatoryresponse depends on redox status and may implicate oxidative stress.Vascular endothelial cells are a direct target of oxidative stress in inflammation.We have tested the impact of the free radical scavenger and antioxidantproperties of betalains from the prickle pear in an in vitro model of endothelialcells. Here we show the capacity of betalains to protect endothelium from cytokine-induced redox state alteration, through ICAM-1 inhibition.KEYWORDS: endothelial cells; ICAM-1; betalains; antiinflammatory drugs

Original language	English
Pages (from-to)	481-486
Number of pages	6
Journal	Annals of the New York Academy of Sciences
Volume	1028
Publication status	Published - 2004

All Science Journal Classification (ASJC) codes

General Neuroscience
General Biochemistry,Genetics and Molecular Biology
History and Philosophy of Science

Cite this

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title = "Antioxidant Betalains from Cactus Pear (Opuntia Ficus Indica) inhibit endothelial ICAM-1 expression",

abstract = "It has been suggested that some pigments would have antioxidantproperties and that their presence in dietary constituents would contribute toreduce the risk of oxidative stress–correlated diseases. Among others, inflammatoryresponse depends on redox status and may implicate oxidative stress.Vascular endothelial cells are a direct target of oxidative stress in inflammation.We have tested the impact of the free radical scavenger and antioxidantproperties of betalains from the prickle pear in an in vitro model of endothelialcells. Here we show the capacity of betalains to protect endothelium from cytokine-induced redox state alteration, through ICAM-1 inhibition.KEYWORDS: endothelial cells; ICAM-1; betalains; antiinflammatory drugs",

author = "Livrea, {Maria Antonia} and Luisa Tesoriere and Carla Gentile and Mario Allegra and D'Alessio",

year = "2004",

language = "English",

volume = "1028",

pages = "481--486",

journal = "Annals of the New York Academy of Sciences",

issn = "0077-8923",

publisher = "Wiley-Blackwell",

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TY - JOUR

T1 - Antioxidant Betalains from Cactus Pear (Opuntia Ficus Indica) inhibit endothelial ICAM-1 expression

AU - Livrea, Maria Antonia

AU - Tesoriere, Luisa

AU - Gentile, Carla

AU - Allegra, Mario

AU - D'Alessio, null

PY - 2004

Y1 - 2004

N2 - It has been suggested that some pigments would have antioxidantproperties and that their presence in dietary constituents would contribute toreduce the risk of oxidative stress–correlated diseases. Among others, inflammatoryresponse depends on redox status and may implicate oxidative stress.Vascular endothelial cells are a direct target of oxidative stress in inflammation.We have tested the impact of the free radical scavenger and antioxidantproperties of betalains from the prickle pear in an in vitro model of endothelialcells. Here we show the capacity of betalains to protect endothelium from cytokine-induced redox state alteration, through ICAM-1 inhibition.KEYWORDS: endothelial cells; ICAM-1; betalains; antiinflammatory drugs

AB - It has been suggested that some pigments would have antioxidantproperties and that their presence in dietary constituents would contribute toreduce the risk of oxidative stress–correlated diseases. Among others, inflammatoryresponse depends on redox status and may implicate oxidative stress.Vascular endothelial cells are a direct target of oxidative stress in inflammation.We have tested the impact of the free radical scavenger and antioxidantproperties of betalains from the prickle pear in an in vitro model of endothelialcells. Here we show the capacity of betalains to protect endothelium from cytokine-induced redox state alteration, through ICAM-1 inhibition.KEYWORDS: endothelial cells; ICAM-1; betalains; antiinflammatory drugs

UR - http://hdl.handle.net/10447/31872

M3 - Article

SN - 0077-8923

VL - 1028

SP - 481

EP - 486

JO - Annals of the New York Academy of Sciences

JF - Annals of the New York Academy of Sciences

ER -

Antioxidant Betalains from Cactus Pear (Opuntia Ficus Indica) inhibit endothelial ICAM-1 expression

Abstract

All Science Journal Classification (ASJC) codes

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