Antioxidant Betalains from Cactus Pear (Opuntia Ficus Indica) inhibit endothelial ICAM-1 expression

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141 Citations (Scopus)


It has been suggested that some pigments would have antioxidantproperties and that their presence in dietary constituents would contribute toreduce the risk of oxidative stress–correlated diseases. Among others, inflammatoryresponse depends on redox status and may implicate oxidative stress.Vascular endothelial cells are a direct target of oxidative stress in inflammation.We have tested the impact of the free radical scavenger and antioxidantproperties of betalains from the prickle pear in an in vitro model of endothelialcells. Here we show the capacity of betalains to protect endothelium from cytokine-induced redox state alteration, through ICAM-1 inhibition.KEYWORDS: endothelial cells; ICAM-1; betalains; antiinflammatory drugs
Original languageEnglish
Pages (from-to)481-486
Number of pages6
JournalAnnals of the New York Academy of Sciences
Publication statusPublished - 2004

All Science Journal Classification (ASJC) codes

  • General Neuroscience
  • General Biochemistry,Genetics and Molecular Biology
  • History and Philosophy of Science


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