Anticancer therapy-induced vascular toxicity: VEGF inhibition and beyond

Giuseppina Novo, Antonio Russo, Giuseppe Badalamenti, Daniela Di Lisi, Ines Monte, Paolo Parrella, Carlo Gabriele Tocchetti, Concetta Zito, Rosalinda Madonna, Enrico Bronte

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26 Citations (Scopus)

Abstract

Cardiotoxicity induced by chemotherapeutic agents and radiotherapy is a growing problem. In recent years, an increasing number of new drugs with targeted action have been designed. These molecules, such as monoclonal antibodies and tyrosine kinase inhibitors, can cause different type of toxicities compared to traditional chemotherapy. However, they can also cause cardiac complications such as heart failure, arterial hypertension, QT interval prolongation and arrhythmias. Currently, a field of intense research is the vascular toxicity induced by new biologic drugs, particularly those which inhibit vascular endothelial growth factor (VEGF) and its receptor (VEGF-R) and other tyrosine kinases. In this review, we aim at focusing on the problem of vascular toxicity induced by new targeted therapies, chemotherapy and radiotherapy, and describe the main mechanisms and emphasizing the importance of early diagnosis of vascular damage, in order to prevent clinical complications.
Original languageEnglish
Pages (from-to)11-17
Number of pages7
JournalINTERNATIONAL JOURNAL OF CARDIOLOGY
Volume227
Publication statusPublished - 2016

All Science Journal Classification (ASJC) codes

  • Cardiology and Cardiovascular Medicine

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  • Cite this

    Novo, G., Russo, A., Badalamenti, G., Di Lisi, D., Monte, I., Parrella, P., Tocchetti, C. G., Zito, C., Madonna, R., & Bronte, E. (2016). Anticancer therapy-induced vascular toxicity: VEGF inhibition and beyond. INTERNATIONAL JOURNAL OF CARDIOLOGY, 227, 11-17.