Analysis of spatial diffusion of ferric ions in PVA-GTA gel dosimeters through magnetic resonance imaging

Luigi Tranchina, Giorgio Collura, Maurizio Marrale, Salvatore Gallo, Maurizio Marrale, Giorgio Collura, Boris Federico Abbate, Salvatore Gallo, Sandra Marineo, Francesco D'Errico, Santo Caracappa, Francesco D'Errico, Stefania Nici

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

This work focused on the analysis of the temporal diffusion of ferric ions through PVA-GTA gel dosimeters.PVA-GTA gel samples, partly exposed with 6 MV X-rays in order to create an initial steep gradient,were mapped using magnetic resonance imaging on a 7T MRI scanner for small animals. Multiple imagesof the gels were acquired over several hours after irradiation and were analyzed to quantitatively extractthe signal profile. The spatial resolution achieved is 200 lm and this makes this technique particularlysuitable for the analysis of steep gradients of ferric ion concentration. The results obtained withPVA-GTA gels were compared with those achieved with agarose gels, which is a standard dosimetricgel formulation. The analysis showed that the diffusion process is much slower (more than five times)for PVA-GTA gels than for agarose ones. Furthermore, it is noteworthy that the diffusion coefficient valueobtained through MRI analysis is significantly consistent with that obtained in separate study Mariniet al. (Submitted for publication) using a totally independent method such as spectrophotometry. Thisis a valuable result highlighting that the good dosimetric features of this gel matrix not only can bereproduced but also can be measured through independent experimental techniques based on differentphysical principles.
Original languageEnglish
Pages (from-to)50-55
Number of pages6
JournalNUCLEAR INSTRUMENTS & METHODS IN PHYSICS RESEARCH. SECTION B, BEAM INTERACTIONS WITH MATERIALS AND ATOMS
Volume396
Publication statusPublished - 2017

Fingerprint

ferric ions
Dosimeters
Magnetic resonance
dosimeters
magnetic resonance
Gels
gels
Imaging techniques
Ions
Magnetic resonance imaging
gradients
Spectrophotometry
spectrophotometry
ion concentration
scanners
animals
Animals
diffusion coefficient
spatial resolution
Irradiation

All Science Journal Classification (ASJC) codes

  • Nuclear and High Energy Physics
  • Instrumentation

Cite this

Analysis of spatial diffusion of ferric ions in PVA-GTA gel dosimeters through magnetic resonance imaging. / Tranchina, Luigi; Collura, Giorgio; Marrale, Maurizio; Gallo, Salvatore; Marrale, Maurizio; Collura, Giorgio; Abbate, Boris Federico; Gallo, Salvatore; Marineo, Sandra; D'Errico, Francesco; Caracappa, Santo; D'Errico, Francesco; Nici, Stefania.

In: NUCLEAR INSTRUMENTS & METHODS IN PHYSICS RESEARCH. SECTION B, BEAM INTERACTIONS WITH MATERIALS AND ATOMS, Vol. 396, 2017, p. 50-55.

Research output: Contribution to journalArticle

Tranchina, Luigi ; Collura, Giorgio ; Marrale, Maurizio ; Gallo, Salvatore ; Marrale, Maurizio ; Collura, Giorgio ; Abbate, Boris Federico ; Gallo, Salvatore ; Marineo, Sandra ; D'Errico, Francesco ; Caracappa, Santo ; D'Errico, Francesco ; Nici, Stefania. / Analysis of spatial diffusion of ferric ions in PVA-GTA gel dosimeters through magnetic resonance imaging. In: NUCLEAR INSTRUMENTS & METHODS IN PHYSICS RESEARCH. SECTION B, BEAM INTERACTIONS WITH MATERIALS AND ATOMS. 2017 ; Vol. 396. pp. 50-55.
@article{4a2a20eedd9847319cda94cdcf31cef2,
title = "Analysis of spatial diffusion of ferric ions in PVA-GTA gel dosimeters through magnetic resonance imaging",
abstract = "This work focused on the analysis of the temporal diffusion of ferric ions through PVA-GTA gel dosimeters.PVA-GTA gel samples, partly exposed with 6 MV X-rays in order to create an initial steep gradient,were mapped using magnetic resonance imaging on a 7T MRI scanner for small animals. Multiple imagesof the gels were acquired over several hours after irradiation and were analyzed to quantitatively extractthe signal profile. The spatial resolution achieved is 200 lm and this makes this technique particularlysuitable for the analysis of steep gradients of ferric ion concentration. The results obtained withPVA-GTA gels were compared with those achieved with agarose gels, which is a standard dosimetricgel formulation. The analysis showed that the diffusion process is much slower (more than five times)for PVA-GTA gels than for agarose ones. Furthermore, it is noteworthy that the diffusion coefficient valueobtained through MRI analysis is significantly consistent with that obtained in separate study Mariniet al. (Submitted for publication) using a totally independent method such as spectrophotometry. Thisis a valuable result highlighting that the good dosimetric features of this gel matrix not only can bereproduced but also can be measured through independent experimental techniques based on differentphysical principles.",
author = "Luigi Tranchina and Giorgio Collura and Maurizio Marrale and Salvatore Gallo and Maurizio Marrale and Giorgio Collura and Abbate, {Boris Federico} and Salvatore Gallo and Sandra Marineo and Francesco D'Errico and Santo Caracappa and Francesco D'Errico and Stefania Nici",
year = "2017",
language = "English",
volume = "396",
pages = "50--55",
journal = "NUCLEAR INSTRUMENTS & METHODS IN PHYSICS RESEARCH. SECTION B, BEAM INTERACTIONS WITH MATERIALS AND ATOMS",
issn = "0168-583X",

}

TY - JOUR

T1 - Analysis of spatial diffusion of ferric ions in PVA-GTA gel dosimeters through magnetic resonance imaging

AU - Tranchina, Luigi

AU - Collura, Giorgio

AU - Marrale, Maurizio

AU - Gallo, Salvatore

AU - Marrale, Maurizio

AU - Collura, Giorgio

AU - Abbate, Boris Federico

AU - Gallo, Salvatore

AU - Marineo, Sandra

AU - D'Errico, Francesco

AU - Caracappa, Santo

AU - D'Errico, Francesco

AU - Nici, Stefania

PY - 2017

Y1 - 2017

N2 - This work focused on the analysis of the temporal diffusion of ferric ions through PVA-GTA gel dosimeters.PVA-GTA gel samples, partly exposed with 6 MV X-rays in order to create an initial steep gradient,were mapped using magnetic resonance imaging on a 7T MRI scanner for small animals. Multiple imagesof the gels were acquired over several hours after irradiation and were analyzed to quantitatively extractthe signal profile. The spatial resolution achieved is 200 lm and this makes this technique particularlysuitable for the analysis of steep gradients of ferric ion concentration. The results obtained withPVA-GTA gels were compared with those achieved with agarose gels, which is a standard dosimetricgel formulation. The analysis showed that the diffusion process is much slower (more than five times)for PVA-GTA gels than for agarose ones. Furthermore, it is noteworthy that the diffusion coefficient valueobtained through MRI analysis is significantly consistent with that obtained in separate study Mariniet al. (Submitted for publication) using a totally independent method such as spectrophotometry. Thisis a valuable result highlighting that the good dosimetric features of this gel matrix not only can bereproduced but also can be measured through independent experimental techniques based on differentphysical principles.

AB - This work focused on the analysis of the temporal diffusion of ferric ions through PVA-GTA gel dosimeters.PVA-GTA gel samples, partly exposed with 6 MV X-rays in order to create an initial steep gradient,were mapped using magnetic resonance imaging on a 7T MRI scanner for small animals. Multiple imagesof the gels were acquired over several hours after irradiation and were analyzed to quantitatively extractthe signal profile. The spatial resolution achieved is 200 lm and this makes this technique particularlysuitable for the analysis of steep gradients of ferric ion concentration. The results obtained withPVA-GTA gels were compared with those achieved with agarose gels, which is a standard dosimetricgel formulation. The analysis showed that the diffusion process is much slower (more than five times)for PVA-GTA gels than for agarose ones. Furthermore, it is noteworthy that the diffusion coefficient valueobtained through MRI analysis is significantly consistent with that obtained in separate study Mariniet al. (Submitted for publication) using a totally independent method such as spectrophotometry. Thisis a valuable result highlighting that the good dosimetric features of this gel matrix not only can bereproduced but also can be measured through independent experimental techniques based on differentphysical principles.

UR - http://hdl.handle.net/10447/221579

M3 - Article

VL - 396

SP - 50

EP - 55

JO - NUCLEAR INSTRUMENTS & METHODS IN PHYSICS RESEARCH. SECTION B, BEAM INTERACTIONS WITH MATERIALS AND ATOMS

JF - NUCLEAR INSTRUMENTS & METHODS IN PHYSICS RESEARCH. SECTION B, BEAM INTERACTIONS WITH MATERIALS AND ATOMS

SN - 0168-583X

ER -