Analysis of IL-6, IL-10 and IL-17 genetic polymorphisms as risk factors for sepsis development in burned patients.

Marisa Palmeri, Gabriella Misiano, Loredana Vaccarino, Giovanni Triolo, Letizia Scola, Giusi Irma Forte, Domenico Lio, Francesco Conte, Antonina Accardo Palumbo, Pileri, D'Arpa, D'Amelio, Salvatore Milano

Research output: Contribution to journalArticle

26 Citations (Scopus)

Abstract

Infection risk, sepsis and mortality after severe burn are primarily determined by patientage, burn size, and depth. Whether genetic differences contribute to otherwise unexpectedvariability in outcomes is unknown. We sought to determine whether there was anassociation between IL-6, IL-10 and IL-17 polymorphisms with cytokine production anddevelopment of sepsis.We evaluated 71 patients with burns 15% TBSA and 109 healthy subjects. The genotypesof IL-6 ( 174C/G), IL-10 ( 819C/T and 1082A/G) and IL-17 (7488T/C) polymorphisms wereidentified applying polymerase chain reaction protocols. The cytokine levels in serum weredetermined with enzyme-linked immunoabsorbent assays.Our results demonstrated no significant differences in the genotype frequencies studiedbetween burn patients and healthy subjects. No significant associations were found amongIL-6 and IL-17F genotypes and the related cytokine serum levels. Only IL-10 promoter 1082GG genotype was related to an increased IL-10 production in burned patients. Inaddition, septic subjects bearing 1082G/G genotype have shown the highest and non-septicbearing 1082A/* genotypes the lowest IL-10 serum levels. All together these data seem toindicate that genetically determined individual difference in IL-10 production might influencethe susceptibility to septic complications in burned patients and suggest that thesemarkers might be useful in burned patient management.
Original languageEnglish
Pages (from-to)208-213
Number of pages6
JournalBurns
Volume38
Publication statusPublished - 2012

All Science Journal Classification (ASJC) codes

  • Surgery
  • Emergency Medicine
  • Critical Care and Intensive Care Medicine

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