An overview on the recent developments of 1,2,4-triazine derivatives as anticancer compounds

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27 Citations (Scopus)

Abstract

The synthesis, the antitumor activity, the SAR and, whenever described, the possible mode of action of 1,2,4-triazine derivatives, their N-oxides, N,. N'-dioxides as well as the benzo- and hetero-fused systems are reported. Herein are treated derivatives disclosed to literature from the beginning of this century up to 2016. Among the three possible triazine isomers, 1,2,4-triazines are the most studied ones and many derivatives having remarkable antitumor activity have been reported in the literature and also patented reaching advanced phases of clinical trials.
Original languageEnglish
Pages (from-to)328-375
Number of pages48
JournalEuropean Journal of Medicinal Chemistry
Volume142
Publication statusPublished - 2017

All Science Journal Classification (ASJC) codes

  • Pharmacology
  • Drug Discovery
  • Organic Chemistry

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