Abstract. Magnesium deficiency is present in several chronic, age-relateddiseases, including cardiovascular, metabolic and neurodegenerative diseases.Alzheimer’s disease (AD) is the most common cause of dementia. The aimof the present study was to study magnesium homeostasis in patients withmild to moderate AD. One hundred and one elderly (≥65 years) patients wereconsecutively recruited (mean age: 73.4±0.8 years; M/F: 42/59). In all patients,a comprehensive geriatric assessment was performed including cognitive andfunctional status. Admission criteria for the AD group (diagnosed according tothe DSM-IV and the NINCDS-ADRDA criteria) included: mild to moderate cognitiveimpairment (MMSE score: 11–24/30, corrected for age and education).Blood samples were analyzed for serum total magnesium (Mg-tot) and serumionized magnesium (Mg-ion). AD patients had significantly lower MMSE scores(20.5±0.7 vs 27.9±0.2; p<0.001), and for the physical function tests. Mg-ion wassignificantly lower in the AD group as compared to age-matched control adultswithout AD (0.50±0.01 mmol/L vs 0.53±0.01 mmol/L; p<0.01). No significantdifferences were found in Mg-tot between the two groups (1.91±0.03 mEq/L vs1.95±0.03 mEq/L; p=NS). For all subjects, Mg-ion levels were significantly anddirectly related only to cognitive function (Mg-ion/MMSE r=0.24 p<0.05), whileno significant correlations were found in this group of patients between magnesiumand ADL or IADL. Our results show the presence of subclinical alterationsin Mg-ion in patients with mild to moderate AD.
Original languageEnglish
Pages (from-to)115-121
Number of pages7
JournalMagnesium Research
Publication statusPublished - 2011

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Molecular Biology
  • Clinical Biochemistry


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