After thefirst successful pregnancy in a liver transplant recipientin 1978, much evidence has accumulatedon the course, outcomes and management strategies of pregnancy following liver transplantation. Generally, liver transplantation restores sexual function and fertility as early as a few months after transplant.Considering that one third of all liver transplant recipients are women, that approximately one-third ofthem are of reproductive age (18–49 years), and that 15% of female liver transplant recipients are paediatric patients who have a >70% probability of reaching reproductive age, the issue of pregnancy afterliver transplantation is rather relevant, and obstetricians, paediatricians, and transplant hepatologistsever more frequently encounter such patients. Pregnancy outcomes for both the mother and infant inliver transplant recipients are generally good, but there is an increased incidence of preterm delivery,hypertension/preeclampsia, foetal growth restriction, and gestational diabetes, which, by definition, render pregnancy in liver transplant recipients a high-risk one. In contrast, the risk of congenital anomaliesand the live birth rate are comparable to those ofthe general population. Currently there are still no robustguidelines on the management of pregnancies after liver transplantation. The aim of this position paperis to review the available evidence on pregnancy in liver transplant recipients and to provide nationalItalian recommendations for clinicians caring for these patients.
|Number of pages||9|
|Journal||Digestive and Liver Disease|
|Publication status||Published - 2016|