Airways hyperresponsiveness and the effects of lung inflation

Nicola Scichilone, Christina Anderlind, Robert Brown, Trigsevgeni Kapsali, George Pyrgos, Nicola Scichilone, Solbert Permutt, Alkis Togias

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32 Citations (Scopus)


Lung inflation has a beneficial effect on the airways of healthy subjects. It acts as a bronchoprotector, that is to prevent bronchoconstriction, and as a bronchodilator, in that it reverses bronchial obstruction. The bronchoprotective effect of deep inspiration is more potent than the bronchodilatory one, and the two phenomena appear to advocate different mechanisms. Asthmatics and rhinitics with airways hyperresponsiveness show an impairment in bronchoprotection induced by deep breaths, whereas the bronchodilatory effect, although reduced, is still effective. The lack of the bronchoprotective effect of deep inspiration may contribute to the development of airways hyperresponsiveness. The mechanisms through which lung inflation exerts its beneficial role in healthy subjects, and the factors impairing such an effect in those with airways hyperresponsiveness, are currently under investigation.
Original languageEnglish
Pages (from-to)262-6-
Number of pages5
JournalInternational Archives of Allergy and Immunology
Publication statusPublished - 2001


All Science Journal Classification (ASJC) codes

  • Immunology and Allergy
  • Immunology

Cite this

Scichilone, N., Anderlind, C., Brown, R., Kapsali, T., Pyrgos, G., Scichilone, N., Permutt, S., & Togias, A. (2001). Airways hyperresponsiveness and the effects of lung inflation. International Archives of Allergy and Immunology, 124, 262-6-.