Agarose/κ-carrageenan-based hydrogel film enriched with natural plant extracts for the treatment of cutaneous wounds

Clelia Dispenza, Maria Antonietta Sabatino, Lorena Anna Ditta, Maria Assunta Costa, Clelia Dispenza, Fiorenza Provenzano, Lorena Anna Ditta, Pier Luigi San Biagio, Estella Rao, Radha Santonocito, Jesús Lozano Sánchez, Maria Assunta Costa, Daniela Giacomazza, Rosa Passantino, Romano Lapasin

Research output: Contribution to journalArticlepeer-review

3 Citations (Scopus)

Abstract

Hydrogels for complex and chronic wound dressings must be conformable, absorb and retain wound exudates and maintain hydration. They can incorporate and release bioactive molecules that can accelerate the healing process. Wound dressings have to be in contact with the wound and epidermis, even for long periods, without causing adverse effects. Hydrogel dressing formulations based on biopolymers derived from terrestrial or marine flora can be relatively inexpensive and well tolerated. In the present article hydrogel films composed by agarose (1.0 wt%), κ-carrageenan at three different concentrations (0.5, 1.0 and 1.5 wt%) and glycerol (3.0 wt%) were prepared without recourse to crosslinking agents, and characterized for their mechanical properties, morphology, swelling and erosion behavior. The films resulted highly elastic and able to absorb and retain large amounts of fluids without losing their integrity. One of the films was loaded with the aqueous extract from Cryphaea heteromalla (Hedw.) D. Mohr for its antioxidant properties. Absence of cytotoxicity and ability to reduce the oxidative stress were demonstrated on NIH-3T3 fibroblast cell cultures. These results encourage further biological evaluations to assess their impact on the healing process.
Original languageEnglish
Pages (from-to)2818-2830
Number of pages13
JournalInternational Journal of Biological Macromolecules
Volume164
Publication statusPublished - 2020

All Science Journal Classification (ASJC) codes

  • Structural Biology
  • Biochemistry
  • Molecular Biology
  • Economics and Econometrics
  • General Energy

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