Aerobic training and angiogenesis activation in patients with stable chronic heart failure: a preliminary report.

Davide Vallese, Adriano Taddeo, Antonino Di Stefano, Davide Vallese, Lorena Delle Donne, Pantaleo Giannuzzi, Silvia Della Bella, Isabella Gnemmi, Silvia Della Bella, Alessandro Mezzani, Ermanno Eleuteri

    Research output: Contribution to journalArticlepeer-review

    20 Citations (Scopus)

    Abstract

    The pathophysiology of chronic heart failure (CHF) involves multiple hystologic and molecular alterations. To determine the effects of physical training on circulating endothelial progenitor cells (EPCs), angiogenesis (angiogenin, angiopoietin-1 and -2, VEGF, Tie-2, SDF-1α) and inflammation (IL-6, CRP), we compared data obtained from 11 CHF pts before and after 3 months aerobic exercise training, to those from 10 non trained CHF pts (CHF-C group, age 64 + 2 years, NYHA 2). At the end of the study, EPCs count and AP-2 serum levels significantly increased in the CHF-TR group. These preliminary data suggest a significant effect of even a short program of physical training on angiogenic activation and endothelial dysfunction.
    Original languageEnglish
    Pages (from-to)418-424
    Number of pages7
    JournalBiomarkers
    Volume18
    Publication statusPublished - 2013

    All Science Journal Classification (ASJC) codes

    • Biochemistry
    • Clinical Biochemistry
    • Health, Toxicology and Mutagenesis

    Fingerprint

    Dive into the research topics of 'Aerobic training and angiogenesis activation in patients with stable chronic heart failure: a preliminary report.'. Together they form a unique fingerprint.

    Cite this