Abstract

During embryonic development, a pool of cells may become a reserve of undifferentiated cells, the embryo-stolen adult stem cells (ESASC). ESASC may be responsible for adult tissue homeostasis, as well as disease development. Transdifferentiation is a sort of reprogramming of ESASC from one germ layer-derived tissue towards another. Transdifferentiation has been described to take place from mesoderm to ectodermal- or endodermal-derived tissues and viceversa but not from ectodermal- to endodermal-derived tissues. We hypothesise that two different populations of ESASC could exist, the first ecto/mesoblast-committed and the second endo/mesoblast-committed. If confirmed, this hypothesis could lead to new studies on the molecular mechanisms of cell differentiation and to a better understanding of the pathogenesis of a number of diseases.
Original languageEnglish
Pages (from-to)83-85
Number of pages3
JournalEUROPEAN JOURNAL OF HISTOCHEMISTRY
Volume51
Publication statusPublished - 2007

All Science Journal Classification (ASJC) codes

  • Anatomy
  • Animal Science and Zoology
  • Developmental Biology
  • Biophysics
  • Histology
  • Cell Biology

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