Administration of a Synbiotic to Free-Living Elderly and Evaluation of SerumCytokines. A Pilot Study

Calogero Caruso, Giuseppina Candore, Sonya Vasto, Marzulli, Martulli, Jirillo, Pugliese, Amati

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32 Citations (Scopus)

Abstract

Ten free-living elderly were administered with a synbiotic [fermented milk containing Lactobacillus rhamnosus Gorbach andGoldin (LGG)] and oligofructose as a prebiotic for one month. Serum cytokines were evaluated before (T0) and after (T1) synbioticadministration. At T0, values of Interleukin (IL)-12, IL-6, IL-10, IL-1 and Tumor Necrosis Factor (TNF)- were lower than normalcontrols, with the exception of IL-8, thus confirming previous results on the impairment of both innate and adaptive responses in elderly.At T1, the synbiotic was able to significantly increase, depressed values of IL-1, IL-6 and IL-8 with a trend to a modest increase for therestant cytokines.In conclusion, the synbiotic used in this study seems to be very beneficial to elderly for its capacity to maintain the immune homeostasis,even if an increase in dosage and prolongation of administration time are required for a better modulation of the aged adaptive immuneresponse.
Original languageEnglish
Number of pages5
JournalCURRENT PHARMACEUTICAL DESIGN
Volume16
Publication statusPublished - 2010

All Science Journal Classification (ASJC) codes

  • Pharmacology
  • Drug Discovery

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