Acetaldehyde and Motivation

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Acetaldehyde contributes to alcohol’s neuroactive effects through its own motivational properties. This chapter gathers current evidence on acetaldehyde psychoactive action, focusing on behavioral investigations able to unveil acetaldehyde rewarding effects and their pharmacological modulation in vivo.Acetaldehyde induces conditioned place preference for paired environment and cues and is dose-dependently self-administered in a two-bottle choice drinking paradigm. Acetaldehyde’s motivational properties are further highlighted by operant paradigms tailored to model several addiction-like behaviors, such as induction and maintenance of operant responding, drug-seeking in extinction, relapse following deprivation, and resistance to punishment. Acetaldehyde-related behaviors are sensitive to pharmacological manipulations of dopamine and endocannabinoid signaling, two systems that functionally interplay in controlling motivation. This evidence holds promising potential for the development of novel pharmacological approaches aimed at reducing alcohol abuse.
Original languageEnglish
Title of host publicationNeuroscience of Alcohol
Pages345-353
Number of pages9
Publication statusPublished - 2019

All Science Journal Classification (ASJC) codes

  • General Medicine
  • General Neuroscience

Fingerprint Dive into the research topics of 'Acetaldehyde and Motivation'. Together they form a unique fingerprint.

Cite this