Absence of an independent association between serum uric acid and left ventricular mass in Caucasian hypertensive women and men

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Abstract

Background and aim: Experimentally uric acid may induce cardiomyocyte growthand interstitial fibrosis of the heart. However, clinical studies exploring the relationshipbetween serum uric acid (SUA) and left ventricular (LV) mass yielded conflicting results.The aim of our study was to evaluate the relationships between SUA and LV mass in a largegroup of Caucasian essential hypertensive subjects.Methods and results: We enrolled 534 hypertensive patients free of cardiovascular complicationsand without severe renal insufficiency. In all subjects routine blood chemistry, includingSUA determination, echocardiographic examination and 24 h ambulatory blood pressure (BP)monitoring were obtained.In the overall population we observed no significant correlation of SUA with LV mass indexedfor height2.7 (LVMH2.7) (r = 0.074). When the same relationship was analysed separately inmen and women, we found a statistically significant correlation in female gender (r = 0.27;p < 0.001), but not in males (r = 0.042; p = NS). When we grouped the study populationin sex-specific tertiles of SUA, an increase in LVMH2.7 was observed in the highest tertiles inwomen (44.5 ± 15.6 vs 47.5 16 vs 55.9 ± 22.2 g/m2.7; p < 0.001), but not in men.The association between SUA and LVMH2.7 in women lost statistical significance in multipleregression analyses, after adjustment for age, 24 h systolic BP, body mass index, serum creatinineand other potential confounders.Conclusions: Our findings do not support an independent association between SUA and LV massin Caucasian men and women with arterial hypertension.
Original languageEnglish
Pages (from-to)715-722
Number of pages8
JournalNMCD. NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES
Volume23
Publication statusPublished - 2013

All Science Journal Classification (ASJC) codes

  • Medicine (miscellaneous)
  • Endocrinology, Diabetes and Metabolism
  • Nutrition and Dietetics
  • Cardiology and Cardiovascular Medicine

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