Abilities of β-Estradiol to interact with chemotherapeutic drugs, signal transduction inhibitors and nutraceuticals and alter the proliferation of pancreatic cancer cells

Giuseppe Montalto, Monica Notarbartolo Di Villarosa, Melchiorre Cervello, Giulia Ramazzotti, Alberto M. Martelli, Saverio Candido, Bruno Bueno-Silva, Stefano Ratti, Severino Matias De Alencar, Agnieszka Gizak, Kvin Lertpiriyapong, Dariusz Rakus, Pedro L. Rosalen, Massimo Libra, Severino Matias De Alencar, Shaw M. Akula, Linda S. Steelman, Marco Falasca, James A. Mccubrey, Ramiro M. MurataLucio Cocco, Giuseppe Montalto, Matilde Y. Follo, Stephen L. Abrams

Research output: Contribution to journalArticle

Abstract

Improving the effects of chemotherapy and reducing the side effects are important goals in cancer research. Various approaches have been examined to enhance the effectiveness of chemotherapy. For example, signal transduction inhibitors or hormonal based approaches have been included with chemo- or radio-therapy. MIA-PaCa-2 and BxPC-3 pancreatic ductal adenocarcinoma (PDAC) cells both express the estrogen receptor (ER). The effects of β-estradiol on the growth of PDAC cells has not been examined yet the ER is expressed in PDAC cells. We have examined the effects of combining β-estradiol with chemotherapeutic drugs, signal transcription inhibitors, natural products and nutraceuticals on PDAC. In most cases, inclusion of β-estradiol with chemotherapeutic drugs increased chemosensitivity. These results indicate some approaches involving β-estradiol which may be used to increase the effectiveness of chemotherapeutic and other drugs on the growth of PDAC.
Original languageEnglish
Pages (from-to)1-15
Number of pages15
JournalAdvances in Biological Regulation
Volume75
Publication statusPublished - 2020

All Science Journal Classification (ASJC) codes

  • Molecular Medicine
  • Molecular Biology
  • Genetics
  • Cancer Research

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  • Cite this

    Montalto, G., Notarbartolo Di Villarosa, M., Cervello, M., Ramazzotti, G., Martelli, A. M., Candido, S., Bueno-Silva, B., Ratti, S., Matias De Alencar, S., Gizak, A., Lertpiriyapong, K., Rakus, D., Rosalen, P. L., Libra, M., Matias De Alencar, S., Akula, S. M., Steelman, L. S., Falasca, M., Mccubrey, J. A., ... Abrams, S. L. (2020). Abilities of β-Estradiol to interact with chemotherapeutic drugs, signal transduction inhibitors and nutraceuticals and alter the proliferation of pancreatic cancer cells. Advances in Biological Regulation, 75, 1-15.