A single amino acid change A19V in perforin: a novel, frequent predisposing factor to childhood acute lymphoblastic leukemia?

Giovanni Corsello, Alessandra Santoro, Maurizio Aricò, Antonino Trizzino, Sonia Cannella

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56 Citations (Scopus)

Abstract

We screened 100 children with acute lymphoblastic leukemia (ALL) to assess the incidence of single amino acid change A91V in perform. Heterozygous A91V was found in 12/100 patients and 5/127 controls (OR, 3.4; 95%CI: 1.15-9.95; p=0.014). A91V is a novel and frequent predisposing factor for childhood ALL.
Original languageEnglish
Pages (from-to)697-698
Number of pages2
JournalHaematologica
Volume90
Publication statusPublished - 2005

All Science Journal Classification (ASJC) codes

  • Hematology

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