A recommended practical approach to the management of target therapy and angiogenesis inhibitors cardiotoxicity: An opinion paper of the working group on drug cardiotoxicity and cardioprotection, Italian Society of Cardiology

Giuseppina Novo, Alessia Pepe, Ines Monte, Christian Cadeddu, Christian Cadeddu, Carlo G. Tocchetti, Concetta Zito, Nicola Maurea, Rosalinda Madonna, Paolo Spallarossa, Pasquale Pagliaro, Giuseppe Mercuro, Donato Mele, Alessia Pepe

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20 Citations (Scopus)

Abstract

The US National Cancer Institute estimates that cardiotoxicity (CTX) from target therapy refers mostly to four groups of drugs: epidermal growth factor receptor 2 inhibitors, angiogenic inhibitors, directed Abelson murine leukemia viral oncogene homolog inhibitors, and proteasome inhibitors. The main cardiotoxic side-effects related to antiepidermal growth factor receptor 2 therapy are left ventricular systolic dysfunction and heart failure. Angiogenesis inhibitors are associated with hypertension, left ventricular dysfunction/heart failure, myocardial ischemia, QT prolongation, and thrombosis. Moreover, other agents may be related to CTX induced by treatment. In this study, we review the guidelines for a practical approach for the management of CTX in patients under anticancer target therapy.
Original languageEnglish
Pages (from-to)93-104
Number of pages12
JournalJournal of Cardiovascular Medicine
Volume17
Publication statusPublished - 2016

All Science Journal Classification (ASJC) codes

  • Cardiology and Cardiovascular Medicine

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    Novo, G., Pepe, A., Monte, I., Cadeddu, C., Cadeddu, C., Tocchetti, C. G., Zito, C., Maurea, N., Madonna, R., Spallarossa, P., Pagliaro, P., Mercuro, G., Mele, D., & Pepe, A. (2016). A recommended practical approach to the management of target therapy and angiogenesis inhibitors cardiotoxicity: An opinion paper of the working group on drug cardiotoxicity and cardioprotection, Italian Society of Cardiology. Journal of Cardiovascular Medicine, 17, 93-104.