A QSAR study investigating the potential anti-HIV-1 effect of some Acyclovir and Ganciclovir analogs

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Abstract

A QSAR study, involving the use of alculated physical-chemical properties (TSARTM), and the use of a neural network approach (TSARTM), has been performed on the potential anti-HIV-1 activity of a series of Acyclovir and Ganciclovir analogs. Model obtained allows reliable predictions for the anti-HIV-1 activity of these derivatives, and showed that the presence of the Ganciclovir chain in triazolopyrrolopyrimidine and pyrimidopyrrolopyrimidine series seems to increase the antiviral effect.
Original languageEnglish
Pages (from-to)85-94
Number of pages10
JournalArkivoc
VolumeVIII
Publication statusPublished - 2009

All Science Journal Classification (ASJC) codes

  • Organic Chemistry

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