A Novel Pathophysiological Mechanism Contributing to Trigeminal Neuralgia

Giovanni Grasso, Alessandro Landi, Concetta Alafaci

Research output: Contribution to journalArticlepeer-review

19 Citations (Scopus)


Trigeminal neuralgia (TN) is a form of neuropathic pain that affects the fifth cranial nerve, the most widely distributed nerve in the head. Although TN has been associated with a variety of pathological conditions, neurovascular compression on the trigeminal nerve, as it exits the brain stem, is the most frequent reported cause. This compression provides a progressive demyelination of the nerve and a subsequent aberrant neural transmission. Although several studies have clarified some physiopathological mechanisms underlying TN, the molecular basis remains vague. Very recently the substitution of methionine 136 by valine (MET126Val) in sodium channel Nav1.6 in a case study of typical TN has suggested a new possible mechanism for TN. The findings of this new mutation provide novel information that warrants further conclusive investigations.
Original languageEnglish
Pages (from-to)452-454
Number of pages3
JournalMolecular Medicine
Publication statusPublished - 2016

All Science Journal Classification (ASJC) codes

  • Molecular Medicine
  • Molecular Biology
  • Genetics
  • Genetics(clinical)


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