A gelatin-thrombin matrix topical hemostatic agent (Floseal) in combination with harmonic scalpel is effective in patients undergoing total thyroidectomy: A prospective, multicenter, single-blind, randomized controlled trial

Gaspare Gulotta, Roberta Lucchini, Paolo Limongelli, Salvatore Tolone, Giuseppe Bellastella, Nicola Avenia, Angela Pezzolla, Gennaro Lupone, Giovanni Docimo, Ludovico Docimo, Nicola Avenia, Domenico Parmeggiani, Massimo Monacelli, Daniela Pasquali, Giovanni Conzo, Katherine Esposito, Roberto Ruggiero, Annamaria De Bellis, Maurizio De Palma, Gianmattia Del Genio

Research output: Contribution to journalArticlepeer-review

24 Citations (Scopus)

Abstract

Background. Hemostasis during thyroidectomy is essential; however, the safest, most efficient, and most cost-effective way to achieve this is unclear. This randomized, multicenter, single-blind, prospective study evaluated the efficacy and safety of using different hemostatic approaches in patients undergoing total thyroidectomy. Methods. Patients aged ≥18 to 70 years were randomized to Floseal + a harmonic scalpel (HS), Floseal alone, HS alone, or standard total thyroidectomy. Primary endpoint was 24-hour drain output. Secondary endpoints included surgery duration and complications. Results. Two hundred and six patients were randomized to Floseal + HS (n = 52), Floseal alone (n = 54), HS alone (n = 50), and standard total thyroidectomy (n = 50). The 24-hour drain output was lower in the Floseal + HS group compared with standard thyroidectomy. Floseal + HS also had a shorter surgery time (P <.0001) versus the other 3 treatments. Conclusion. Floseal + HS can be effective at reducing postsurgical drain output and provides a complementary hemostatic approach in patients undergoing total thyroidectomy.
Original languageEnglish
Pages (from-to)23-29
Number of pages7
JournalSurgical Innovation
Volume23
Publication statusPublished - 2016

All Science Journal Classification (ASJC) codes

  • Surgery

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