A close connection: Alzheimer’s disease and type 2 diabetes

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In the recent years a growing body of evidencelinks insulin resistance and insulin action toneurodegenerative diseases, especially Alzheimer’sdisease (AD). The importance of insulin in ageingas well as its role in cognition and other aspects ofnormal brain functions are well established. Thehippocampus and cerebral cortex-distributed insulinand insulin receptor (IR) have been shown to beinvolved in brain cognitive functions. Conversely,deterioration of IR signaling is involved in agingrelatedbrain degeneration such as in AD andcognitive impairment in type 2 diabetes patients.Insulin administration, while maintainingeuglycemia, improves memory in both healthyadults and Alzheimer’s disease patients. In thepresent review, some common links between ADand type 2 diabetes are presented. Furthermore,several biochemical aspects existing in bothpathologies are highlighted.
Original languageEnglish
Number of pages13
Publication statusPublished - 2012

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